Beijing University of Technology

Simon John Mountford

William Roy Jackson

Siew Yeen Chai

Philip E Thompson

Michael William Parker

Milton T W Hearn

Anjali Makarand Bhagwat

The present disclosure relates generally, but not exclusively, to compounds and their use in therapy, to compositions and agents comprising said compounds, to methods of treatment using said compounds, and their use in the manufacture of medicaments. The disclosure further relates to inhibitors of IRAP and their use in the treatment or prevention of Alzheimer's disease and the treatment and prevention of memory and cognitive disorders.

4H-pyran compounds as insulin-regulated aminopeptidase (IRAP) inhibitors

The present invention relates generally to affinity ligands and chemical affinity ligand-matrix conjugates for use as chromatographic adsorbents and methods which utilize the adsorbents in the purification of proteins by affinity chromatography. The affinity ligand-matrix conjugates of the present invention comprise ligands of general formula (I): wherein m represents an integer from 0-2, n represents an integer from 0-6, p represents an integer from 0-4, Rrepresents H or Calkyl, Ris an optional substituent, and X is the position at which the ligand is immobilized, optionally via a linker. 

Affinity ligands and methods for protein purification

Growing community of inventors

Beaconsfield, Australia

Simon John Mountford