Biota Scientific Management Pty Ltd

Simon J F MacDonald

Stephen E Shanahan

Wen-Yang Wu

Derek Anthony Demaine

Darryl McConnell

Betty Jin

Van T T Nguyen

Andrew McM Mason

Keith G Watson

Simon P Tucker

Graham G A Inglis

Haydn T Jones

Michael D Dowle

The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; Ris acetyl or trifluoroacetyl; and n is an integer from 10 to 18 or a pharmaceutically acceptable derivative thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.

Dimeric compounds and their use as anti-viral agents

The invention relates to compounds of general formula (I), in which: R is an amino or guanidino group; Ris acetyl or trifluoroacetyl; n and q are either the same or different and selected from 0, 1 or 2; and X is an optionally substituted phenyl, optionally substituted naphthyl or optionally substituted phenyl-Y-optionally substituted phenyl in which Y is selected from a covalent bond, CH, CHCH, O or SO, or a pharmaceutically acceptable derivative thereof, with the proviso that when X is phenyl or naphthyl, n and q are both 2 and when X is phenyl-Y-phenyl in which Y is a covalent bond, then n and q are not both 0, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.

The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; Ris acetyl or trifluoroacetyl; X is CONH, NHCO or O; n is an integer from 2 to 6; and Y is C-Calkyl Ccycloalkyl, C-Calkoxyalkyl, an amino acid or dipeptide, or a pharmaceutically acceptable derivative thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection.

The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; Ris acetyl or trifluoroacetyl; and n is an integer from 10 to 18 or a pharmaceutically acceptable derivative thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection 

The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; Ris acetyl or trifluoroacetyl; X is CONH, NHCO or O; n is an integer from 2 to 6; and Y is C&#x2013;Calkyl Ccycloalkyl, C&#x2013;Calkoxyalkyl, an amino acid or dipeptide, or a pharmaceutically acceptable derivative thereof, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection 

The invention relates to compounds of general formula (I), in which: R is an amino or guanidino group; Ris acetyl or trifluoroacetyl; n and q are either the same or different and selected from 0, 1 or 2; and X is an optionally substituted phenyl, optionally substituted naphthyl or optionally substituted phenyl-Y-optionally substituted phenyl in which Y is selected from a covalent bond, CH, CHCH, O or SO, or a pharmaceutically acceptable derivative thereof, with the proviso that when X is phenyl or naphthyl, n and q are both 2 and when X is phenyl-Y-phenyl in which Y is a covalent bond, then n and q are not both 0, methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection 

The invention relates to compounds of general formula (I); in which R is an amino or guanidino group; Ris acetyl or trifluoroacetyl; X is CONH, SONH, NHCO or NHCONH; m is either 0 or 1; n is an integer from 2 to 6; q is an integer from 0 to 3; and Y is hydrogen or an aromatic substituent, or a pharmaceutically acceptable derivative thereof; methods for their preparation, pharmaceutical formulations containing them or their use in the prevention or treatment of a viral infection 

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Stevenage, United Kingdom

Simon J F MacDonald