University of California

Massachusetts Institute of Technology

Simon H Friedman

Raymond F Schinazi

Fred Wudl

Craig L Hill

George Lommel Kenyon

Rintje Pieter Sijbesma

Diane L DeCamp

John I Clark

Roelant J Siezen

John A Thomson

George B Benedek

Geroge B Benedek

Diane L De Camp

A water soluble derivative of buckministerfullerene (C) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.

Method of treatment of viral infection including HIV using water soluble fullerenes&#x2014;III

A water soluble derivative of buckministerfullerene (C ) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.

Method of treatment of viral infection including HIV using water soluble fullerenes

A water soluble derivative of buckministerfullerene (C,) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.

Water soluble fullerenes with antiviral activity

A water soluble derivative of buckministerfullerene (C.sub.60) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.

The present invention relates to methods and pharmaceutical reagents for decreasing the phase separation temperature and inhibiting the formation of high molecular weight aggregates in eye lenses, thereby inhibiting or reversing cataract formation.

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San Francisco, CA, United States of America

Simon H Friedman