Genentech, Inc.

F. Hoffmann-la Roche Ag

Simon Gaines

Monique Bodil Van Niel

Benjamin Fauber

Stuart Ward

Olivier Rene

David Robert Vesey

Alberto Gobbi

Emanuela Gancia

Paul Winship

Tammy Ladduwahetty

Christopher Hurley

Jonathan Killen

David Vesey

Tammy Laddywahetty

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, X, X, X, X, Y, Z, A, R, R, R, R, RR, R, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis, muscular sclerosis and psoriasis.

Aryl sultam derivatives as RORc modulators

Compounds of the formula I: or pharmaceutically acceptable salts thereof,wherein m, n, p, q, r, A, W, X, X, X, X, Y, Z, R, R, R, R, R, R, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Compounds of the formula Ia or Ib: or pharmaceutically acceptable salts thereof,wherein m, n, p, q, r, A, X, X, X, X, Y, Z, R, R, R, R, R, R, R, and Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Benzyl sulfonamide derivatives as RORc modulators

Compounds of the formula I: or pharmaceutically acceptable salts thereof,wherein m, n, p, q, r, A, W, X, X, X, X, Y, Z, R, R, R, R, R, R, R, R, R, R, R, and Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Growing community of inventors

Harlow, United Kingdom

Simon Gaines