Duke University

University of California

The University of Texas System

Case Western Reserve University

Vanderbilt University

Simon G Gregory

Mariano A Garcia-Blanco

Jeffery M Vance

Shelton S Bradrick

Gaddiel Galarza-Munoz

Elizabeth R Hauser

William E Kraus

Pascal J Goldschmidt

Lisa F Barcellos

Irina Evsyukova

Farren B S Briggs

Dennis C Ko

Margaret A Pericak-Vance

Eric Benner

Jonathan L Haines

Silke Schmidt

The present invention includes a method, kits, and assays for identifying a human subject as having an increased risk of developing an autoimmune disease, or a human subject with multiple sclerosis caused by elevated soluble Interleukin 7 receptor (sIL7R), by obtaining a biological sample and detecting or measuring in the biological sample an amount of a soluble Interleukin-7 receptor (sIL7R) and an amount of an RNA Helicase DDX39B, whereby a lower expression of DDX39B and a higher secretion of sIL7R identifies the subject from which the biological sample was obtained as having an increased risk of developing an autoimmune disease, when compared to a human subject not having an autoimmune disease. The present invention also includes a method of modifying a treating of subjects based on the lower expression of RNA Helicase DDX39B alone or in combination with an increase in sIL7R.

Method to identify subjects at higher risk to develop an autoimmune disease based on genetic and/or phenotypic screening for epistatic variants in DDX39B (RS2523506) and IL7R (RS6897932)

Described are oxysterols, pharmaceutical compositions including the oxysterols, and methods of using the oxysterols and compositions for treating diseases and/or disorders related to inflammation, such as necrotizing enterocolitis, mesenteric ischemia, inflammatory bowel diseases including Crohn's disease and ulcerative colitis, lymphocytic colitis, Celiac disease. Behcet's disease, rheumatoid arthritis, psoriasis, and autoimmune thyroid disease.

Compositions and methods for the treatment of myelin related and inflammation related diseases or disorders

The present invention provides, in certain aspects, a method of identifying a subject as having an increased risk of developing multiple sclerosis, comprising detecting in the subject the presence of a nucleotide variant in the interleukin 7 receptor alpha chain gene, whereby the presence of said variant identifies the subject as having an increased risk of developing multiple sclerosis.

Methods and compositions for correlating genetic markers with multiple sclerosis

The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising:

Methods for identifying an individual at increased risk of developing coronary artery disease

Growing community of inventors

Durham, NC, United States of America

Simon G Gregory