University of York

Bruker Biospin Gmbh

Simon Benedict Duckett

Antonio Giuseppe Gianotti

Gary George Green

Martin Hofmann

Joost Lohman

Joost A B Lohman

Kate M Appleby

Maria-Alexandra Olaru

Wissam Iali

Joaquin Lopez-Serrano

Paul Ian Elliott

Gary George Reginald Green

Soumya Singha Roy

Michael James Cowley

Joaquim Lopez-Serrano

Alexandra Maria Olaru

Paul Ian Parker Elliott

Antonio Gianotti

Joachin Lopez-Serrano

There is described a method for the preparation of an aqueous magnetic resonance imaging medium, said method comprising the steps of: •(i) preparing a multiphasic solvent system comprising an aqueous component and a non-aqueous component, said solvent comprising a target substrate and a SABRE hyperpolarisation transfer catalyst; •(ii) adding Hor parahydrogen gas; •(iii) agitating the solvent system to form an emulsion thereby transferring the spin order from the hyperpolarisation transfer catalyst to the target substrate; •(v) adding a solvent phase-separation promoter; and •(vi) separating the non-aqueous component and the aqueous component wherein the aqueous component contains the hyperpolarised target substrate and provides the aqueous magnetic resonance imaging medium.

Hyperpolarisation in aqueous media via sabre

There is described a method for preparation of an imaging medium via transfer from a hyperpolarised singlet state that is not parahydrogen, said method comprising the steps of: (i) preparing a system containing: parahydrogen; a magnetisation transfer complex, with a molecular symmetry that allows the creation of a singlet state between spin pairs within it, said complex including a reversibly bound small molecule transference substrate; applying a magnetic field such that hyperpolarisation is transferred into the transfer complex, including the reversibly bound small molecule transference substrate; (ii) introducing a recipient complex capable of binding the small molecule transference substrate, said recipient complex including a recipient substrate, such that the recipient complex and recipient substrate, including the bound transference substrate, is hyperpolarised.

Polarisation transfer via a second metal complex

An NMR experiment on hyperpolarizable magnetic nuclei of substrate molecules in a living human or animal body, involves polarizing the substrate molecules by non-hydrogenating para-hydrogen induced polarization (=NH-PHIP) into a singlet/pseudo singlet state in low magnetic field and injecting the substrate molecules into the living body, the body or a part thereof being previously located inside a magnet at low magnetic field. The magnet is switched on to high magnetic field, and in at least part of the substrate molecules, the singlet state/pseudo singlet state is converted into observable magnetization. An MRI or MRS measurement is carried out with the living body or the part thereof, collecting data from the substrate molecules. The NMR experiment is well applicable on hyperpolarized nuclei within a patient, with reduced losses of magnetization due to relaxation processes.

Field cycling method for magnetic resonance

The invention relates to a device () for the preparation and measurement of a nuclear spin resonance (NMR) measurement sample (), including&#x2014;a flow-through NMR probehead (), with a first tube () and a second tube () each for the supply and removal of a liquid NMR measurement sample (),&#x2014;at least one chamber () which is connected to one of the tubes (),&#x2014;a sample inlet () for introducing the liquid measurement sample () into the device (), wherein at least one chamber () has at least one connection for increasing () and releasing () the gas pressure, and in which at least one chamber () comprises means for mixing the liquid measurement sample () contained in the chamber () with a gas With the inventive device it is possible to reduce the measurement sample consumption when doing an NMR spectroscopic measurement on liquid measurement samples to which spin order can be catalytically transferred.

NMR measurement apparatus with flow-through probehead

An NMR method is presented having enhanced sensitivity on a compound comprising hyperpolarizable nuclei, in particular applying enhanced PHIP. Polarization is thereby transferred from a prepared fluid, which is enriched with symmetric molecules of a particular spin state (e.g. para-hydrogen enriched), directly to the hyperpolarizable nuclei of a compound, without altering the chemical identity of the compound in this process. Spin transfer is achieved using a template having sites of ordered environment, and the fluid and the compound are brought together in the presence of the template. Polarization transfer to the hyperpolarizable nuclei of the compound is thereby easier to perform and can be applied to a broader scope of compounds.

Hyperpolaritzation of compounds for NMR, in particular by means of PHIP

Growing community of inventors

Heslington/York, United Kingdom

Simon Benedict Duckett