Amgen Inc.

Simon A Burkitt

Christopher Neil Farthing

Juan Carlos Jaen

Dustin L McMinn

Timothy David Cushing

David John Kopecky

Xiaolin Hao

Marc Labelle

Youngsook Shin

Mario G Cardozo

Michael R Degraffenreid

Sarah Elizabeth Lively

Marie-Louise Smith

Andrew Smith

Sven P Rasmussen

David Craig McGowan

Frank Kayser

Xiaotian Zhu

Rajiv Sharma

Sarah Lively

Erin F DiMauro

John Laird Buchanan

Jinqian Liu

Xian Yun Jiao

XianYun Jiao

Stephen J Shuttleworth

William H Buckner

Alexander David Frenkel

Teresa L Marshall

Martin J Harrison

The present invention relates to furanopyrimidine compounds having the general Formula I: and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of treating various diseases and conditions in a mammal, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma and thymoma, comprising administering to the mammal a therapeutically effective amount of a compound of Formula I. The invention also relates to methods of manufacturing medicaments, which comprise one or more compounds of Formula I.

Furanopyrimidines

Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic, infectious and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism, infection and cell proliferation. The subject compounds contain a fused heterobicyclic ring.

Antiinflammation agents

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Kirkby-in-Ashfield, United Kingdom

Simon A Burkitt