Avon Products, Inc.

New Avon LLC

Siming W Chen

Qian Zheng

John W Lyga

Uma Santhanam

Russell J Wyborski

Dmitri S Ptchelintsev

Daniel Thorn Leeson

Satish Parimoo

Permanan Raaj Khusial

Xiaochun Luo

Dimitri S Ptchelintsev

Russell J Wyborskin

The present disclosure relates to methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, by application of one or a combination of natural compounds or extracts that stimulate MAGP-1 expression and which improves the appearance of aged and/or photodamaged skin. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof in an amount effective to improve the condition and aesthetic appearance of skin.

Compositions and methods for stimulation MAGP-1 to improve the appearance of skin

Cosmetic compositions comprising one or more paxillin stimulators and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The paxillin stimulators and combinations thereof are believed to have modulatory activity against at least one biochemical pathway implicated in skin aging.

Extract for treating wrinkles and/or fine lines

Methods and compositions for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ a botanical extract of, or combinations thereof and a cosmetically acceptable vehicle.

Collagen and elastin stimulating compositions and uses thereof

Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents, other than a retinoid, that stimulate thymosin beta-4 expression in the skin. Also provided are methods for screening for substances which stimulate thymosin beta-4 expression levels and the methods of using active agents identified by the screening protocol in the treatment of skin.

Modulation of thymosin beta-4 in skin

Paxillin stimulating compositions and cosmetic uses thereof

Methods of using extracts ofto impart anti-aging benefits to skin and/or improve skin conditions resulting from aging or damaged skin.

[object Object]

Topical compositions and methods of use to treat symptoms of reduced skin elasticity are provided comprising desthiobiotin and certain desthiobiotin analogues. These compounds are effective in stimulating LOXL-1 activity and can thus increase elastin remodeling and improve appearance of fine lines, wrinkles, skin sagging and other symptoms of reduced elastin function.

Growing community of inventors

Basking Ridge, NJ, United States of America

Siming W Chen