Fluidigm Corporation

Bio-rad Laboratories, Inc.

A9.com, Inc.

Bossa Nova Robotics Ip, Inc.

Simant Dube

Serge Saxonov

Gang Sun

John Frederick Regan

Lian-She Zhao

Kevin D Ness

Benjamin J Hindson

Sunil Ramesh

Arnab Sanat Kumar Dhua

Colin Jon Taylor

Xiaofan Lin

Nicholas Heredia

Jeffrey Mellen

Austin So

Ramesh Ramakrishnan

Jaishanker K Pillai

Phillip Belgrader

Bernhard Zimmermann

Michael Ybarra Lucero

Billy Wayne Colston, Jr

Sarjoun Skaff

Edward Hsiao

Alain Mir

Stephen Vincent Williams

Lesley Suzanne Weaver

Jonathan Davis Taylor

Adam McCoy

Yann Jouvenot

Phil Belgrader

Jian Qin

Ben Hindson

Mike Lucero

Bill Colston

Adam M McCOY

Nicholas Jack Heredia

Jeffrey Clark Mellen

Method of haplotype analysis. In an exemplary method, an aqueous phase containing nucleic acid may be partitioned into a plurality of discrete volumes. At least one allele sequence may be amplified in the volumes from each of a first polymorphic locus and a second polymorphic locus that exhibit sequence variation in the nucleic acid. At least one measure of co-amplification of allele sequences from both loci in the same volumes may be determined. A haplotype of the first and second loci may be selected based on the at least one measure of co-amplification.

Analysis of nucleic acids

A system for building a product library without requiring a planogram includes an image capture unit operated to provide images of items. Taking data from a shelf label detector and depth map creation unit, a processing module can be used to compare detected shelf labels to a depth map, define a product bounding box, and associate the bounding box with an image provided by the image capture unit to build image descriptors. The system can include one or more autonomous robots for supporting and moving the image capture unit and other components.

System and method for locating, identifying and counting items

An object recognition system can be adapted to recognize subject matter having very few features or limited or no texture. A feature-sparse or texture-limited object can be recognized by complementing local features and/or texture features with color, region-based, shape-based, three-dimensional (3D), global, and/or composite features. Machine learning algorithms can be used to classify such objects, and image matching and verification can be adapted to the classification. Further, multiple modes of input can be integrated at various stages of the object recognition processing pipeline. These multi-modal inputs can include user feedback, additional images representing different perspectives of the object or specific regions of the object including a logo or text corresponding to the object, user behavior data, location, among others.

Object recognition of feature-sparse or texture-limited subject matter

A manually assisted robot inventory monitoring method provides for detecting and reading shelf labels using an autonomous robot. Bounding boxes around possible products in a panoramic image can be taken with at least one camera associated with the autonomous robot. Products in the bounding boxes are automatically identified, with those that are not being later manually identified.

Planogram assisted inventory system and method

Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g. whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles.

Various embodiments may increase scalability of image representations stored in a database for use in image matching and retrieval. For example, a system providing image matching can obtain images of a number of inventory items, extract features from each image using a feature extraction algorithm, and transform the same into their feature descriptor representations. These feature descriptor representations can be subsequently stored and used to compare against query images submitted by users. Though the size of each feature descriptor representation isn't particularly large, the total number of these descriptors requires a substantial amount of storage space. Accordingly, feature descriptor representations are compressed to minimize storage and, in one example, machine learning can be used to compensate for information lost as a result of the compression.

Scalable image matching

System, including methods and apparatus, for performing a multiplexed digital assay.

Multiplexed digital assays

A method of estimating a concentration of DNA molecules in a biological sample includes storing a number of a plurality of reaction sites in a memory and distributing the biological sample among the plurality of reaction sites. The method also includes determining a number of the plurality of reaction sites characterized by a presence of one or more of the DNA molecules and computing a portion of the plurality of reaction sites characterized by the presence of the one or more of the DNA molecules. The method further includes estimating the concentration of the DNA molecules as a function of the portion of the plurality of reaction sites and computing a confidence interval for the estimated concentration of DNA molecules.

Method and apparatus for determining copy number variation using digital PCR

System, including methods, apparatus, and compositions, for performing a multiplexed digital assay on a greater number of targets through combinatorial use of signals.

Multiplexed digital assays with combinatorial use of signals

Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g., whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles.

System, including methods and apparatus, for performing a digital assay with multiplexed detection of two or more distinct targets in the same optical channel.

Digital assays with multiplexed detection of two or more targets in the same optical channel

The present invention provides for determining relative copy number difference for one or more target nucleic acid sequences between a test sample and a reference sample or reference value derived therefrom. The methods facilitate the detection of copy number differences less than 1.5-fold.

Determination of copy number differences by amplification

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Berkeley, CA, United States of America

Simant Dube