Adama Agan Ltd.

Pharmos Corporation

Clevexel Pharma

Adam Agan Ltd.

Dynamix Pharmaceuticals Ltd.

Sima Mirilashvili

Avihai Yacovan

Yaniv Barda

Oren Becker

Vered Behar

Nili Schutz

Efrat Ben-Zeev

Alina Shitrit

Bhoopal Meka

Sreedevi Mannam

Bhavinkumar P Hamirani

Shmuel A Baron

Bijukumar Gopinathan Pillai

Gali Golan

Iris Alroy

Alex Aizikovich

Doron Pappo

Alexander Aizikovich

Itai Bloch

Sharon Gazal

Alexander Konson

Rachel Ozeri

Tzofit Kehat

Daniel Sherman

Osnat Kashtan

Flavio Grynszpan

Oren M Becker

A process for preparing, 1,1,3-trioxo-1,2-benzothiazole-6-carboxamide of formula (I) comprising: (a) oxidizing 2,5-dimethyl-benzenesulfonamide of formula (II) in the presence of an oxidizing agent to receive 2-sulfamoyl-terephthalic acid of formula (III); (b) converting the formed 2-sulfamoyl-terephthalic acid of formula (III) to receive 2-sulfonoyl-terephthalic acid derivative of formula (IV); and (c) reacting the resulting 2-sulfamoyl-terephthalic acid derivative of formula (IV) with ammonia (NH) or ammonium containing-salt; wherein R represents OR′ or CI and R′ represents a branched or non-branched C-Calkyl.

Process for preparing 1,1,3-trioxo-1,2-benzothiazole-6-carboxamide

The present subject matter relates to a process for separating compound (I) from a mixture comprising compound (I). The present subject matter also relates to a process for separating compound (I) from a mixture comprising compound (I) and compound (II).

Separation of phenol isomer

A process for preparing, 1,1,3-trioxo-1,2-benzothiazole-6-carboxamide of formula (I) comprising: (a) oxidizing 2,5-dimethyl-benzenesulfonamide of formula (II) in the presence of an oxidizing agent to receive 2-sulfamoyl-terephthalic acid of formula (III); (b) converting the formed 2-sulfamoyl-terephthalic acid of formula (III) to receive 2-sulfamoyl-terephthalic acid derivative of formula (IV); and (c) reacting the resulting 2-sulfamoyl-terephthalic acid derivative of formula (IV) with ammonia (NH) or ammonium containing-salt; wherein R represents OR' or CI and R&#x2032; represents a branched or non-branched C-Calkyl.

A process for preparing, 1,1,3-Trioxo-1,2-benzothiazole-6-carboxamide of formula (I) comprising: reacting 2-chloro-sulfonyl-terephthalic acid dialkyl ester of formula (II) with ammonia (N H) or ammonium containing-salt; wherein R represents a branched or non-branched C-Calkyl.

The invention provides sulfonamide compounds of formula (I) as defined herein, pharmaceutical compositions containing the same and methods of treatment using such compounds and pharmaceutical compositions. These compounds have a common wide range of beneficial therapeutic indications, in particular as analgesic and anti-inflammatory agents.

Sulfonamide derivatives with therapeutic indications

The invention relates to compounds and methods for modulating one or more components of a kinase signaling cascade.

Compositions and methods for modulating a kinase

The invention relates to sulfonamide compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.

Sulfonamides for the modulation of PKM2

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Lod, Israel

Sima Mirilashvili