Wyeth

American Home Products Corporation

Silvio Iera

Warren Chew

Galina Vid

Jianxin Ren

Zhixian Ding

Timothy Thomas Curran

John Hamilton Sellstedt

Panolil C Raveendranath

John R Potoski

Gregg Brian Feigelson

Joseph Zeldis

John Leo Considine

Scott Mason Duncan

Sylvain Daigneault

Anita W Chan

Christopher Demerson

Arthur G Mohan

John Potoski

Michel Bernatchez

Maria Papamichelakis

Wayne G McMahon

Jacqueline F Lunetta

Michael F MacEwan

Pierre Giguere

Graziano Castaldi

Giuseppe Barreca

Mannching Sherry Ku

Anita Wai-Yin Chan

Vincenzo Cannata

Kadum A Ali

Marc Sadler Tesconi

Hong Wen

Antonia Nikitenko

Abdolsamad Tadayon

Greg Feigelson

Jiaxin Ren

Jiaxen Ren

John Richard Potoski

This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms.

Antineoplastic combinations

The present invention is directed to monohydrate and anhydrate crystal forms of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol, an estrogenic receptor modulator useful in the treatment of, for example, diseases related to abnormal levels of estrogen.

Crystal forms of 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol

The present invention is directed to a crystalline polymorph of bazedoxifene acetate, compositions containing the same, preparations thereof, and uses thereof.

Crystalline polymorph of bazedoxifene acetate

The present invention provides processes for the purification of substituted benzoxazole compounds, and in particular 2-(3-fluoro-4-hydroxy-phenyl)-7-vinyl-benzooxazol-5-ol. The processes include recrystallizing the compound from a solution comprising acetone and acetonitrile; treating the crude purified product with a clarifying agent in a solution comprising ethyl acetate, and precipitating or triturating the compound from a mixed solvent system.

Process for the purification of substituted benzoxazole compounds

Methods of preparing compounds of Formula I are provided.

Process for the synthesis of derivatives of halo-[2,3-F] quinoline

Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino-[2,3-f] quinoline

This invention provides a compound of Formula (I): wherein

Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines

Methods of preparing compounds of Formula Iare provided.

Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline

The present invention provides a new process and intermediates for the production of antiviral compound 4',4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2&#x2032;-disulfonic acid and its pharmaceutically acceptable salts.

Preparation and purification of antiviral disulfonic acid disodium salt

The present invention provides a new process and intermediates for the production of antiviral compound 4&prime;,4-bis-&lcub;4,6-bis-&lsqb;3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino&rsqb;-&lsqb;1,3,5&rsqb;triazin-2-ylamino&rcub;-biphenyl-2,2&prime;-disulfonic acid and its pharmaceutically acceptable salts.

Process for the synthesis of derivatives of 2,3-dihydro-1,4-dioxino- &lsqb;2,3-f&rsqb; quinoline

The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula:

Aryloxy-alkyl-dialkylamines

The present invention provides compounds useful in the synthesis of biologically active compounds, and processes for their production, the compounds having the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are, independently, selected from H; C.sub.1 -C.sub.12 alkyl or C.sub.1 -C.sub.6 perfluorinated alkyl; X represents a leaving group; A is O or S; m is an integer from 1 to 3, preferably 2; R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are independently selected from H, halogen, --NO.sub.2, alkyl, alkoxy, C.sub.1 -C.sub.6 perfluorinated alkyl, OH or the C.sub.1 -C.sub.4 esters or alkyl ethers thereof, --CN, --O--R.sup.1, --O--Ar, --S--R.sup.1, --S--Ar, --SO--R.sup.1, --SO--Ar, --SO.sub.2 --R.sup.1, --SO.sub.2 --Ar, --CO--R.sup.1, --CO--Ar, --CO.sub.2 --R.sup.1, or --CO.sub.2 --Ar; and Y is selected from a) the moiety: ##STR2## wherein R.sub.7 and R.sub.8 are independently selected from the group of H, C.sub.1 -C.sub.6 alkyl, or phenyl; or b) an optionally substituted five-, six- or seven-membered saturated, unsaturated or partially unsaturated heterocycle or bicyclic heterocycle containing up to two heteroatoms selected from the group consisting of --O--, --NH--, --N(C.sub.1 C.sub.4 alkyl)--, --N.dbd., and --S(O).sub.n --.

Growing community of inventors

Montreal, Canada

Silvio Iera