Bracco Imaging S.p.a.

Other

Kao Corporation

Bracco S.p.a.

Universitá Degli Studi Di Torino

Silvio Aime

Fulvio Uggeri

Enzo Terreno

Luciano Lattuada

Giovanni Battista Giovenzana

Daniela Delli Castelli

Pierfrancesco Morosini

Massimo Visigalli

Franco Fedeli

Valentina Mainero

Dario Livio Longo

Kondareddiar Ramalingam

Roberta Napolitano

Valeria Boi

Mathilde H Lerche

Fabio Tedoldi

Magnus Karlsson

Pernille Rose Jensen

Francesca Reineri

Alberto Fringuello Mingo

Rolf E Swenson

Alessandro Maiocchi

Carlo Scolastico

Leonardo Manzoni

Claudia Cabella

Luisella Calabi

Sonia Colombo Serra

Camilla Cavallotti

Alessandro Barge

Mauro Botta

Massimo Sisti

Giovanni Palmisano

Matteo Galli

Daniela Arosio

Tommaso Boi

Erika Cerutti

Simonetta Chirich Geninatti

Edmund R Marinelli

Bo Song

Keiji Monda

Simona Ghiani

Luisa Poggi

Roberto Gobetto

Walter Dastru′

Giuseppe Ferrauto

Eliana Gianolio

Simona Baroni

Carlo Nervi

Ramalingam Kondareddiar

Marco Crosetti

Linda Chaabane

Vito Lorusso

Walter Dastrù

Alessandra Viale

Joseph Stancanello

Daniela Santelia

Martina Tripepi

Lorena Consolino

Francesca Arena

Walter Dastru'

The present invention refers to pharmaceutical compositions comprising a macrocyclic gadolinium complex and a water-soluble polyarylene additive useful in diagnostic imaging as diagnostic agents, in particular as contrast agents, specifically in Magnetic Resonance Imaging (MRI).

Pharmaceutical compositions comprising Gd-complexes and polyarylene additives

The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

Contrast agents

The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

The present invention relates to a process for the preparation of aqueous solutions of [1-C]-hyperpolarized carboxylate containing molecules of diagnostic interest that comprises parahydrogenating with molecular parahydrogen unsaturated alkenyl or alkynyl esters of the concernedC-carboxylate molecules.

Process for the preparation of hyperpolarized carboxylate compounds

The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.

CEST systems exhibiting a concentration independent responsiveness

The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable stereoisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable stereoisomers in solution useful as concentration independent CEST responsive agents.

The present invention generally relates to a composition comprising acetic anhydride, a DNP agent and a gadolinium complex and its use for the preparation of hyperpolarised imaging agent for MR diagnostic analysis.

Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis

The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.

Process for preparing hyperpolarized substrates and method for MRI

The present invention relates to a process for the preparation of aqueous solutions of hyperpolarized carboxylic organic acids ready for use in in-vivo MR diagnostic imaging, and the use of the corresponding anhydrides or esters as glass-forming agents.

Process for the preparation of hyperpolarized derivatives for use in MRI analysis

The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.

Integrin targeted synthetic ligands for diagnostic and therapeutic applications

The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel peptides able to bind fibrin, to a process for their preparation and to compositions thereof for use in therapy and diagnostics. The compounds of the invention bind, in particular, to fibrin present in the extracellular matrix (EC) of tumor or connective tissue of stroma thus acting as targeting moieties able to bring and successfully bound an active moiety linked thereto to fibrin depositions inside solid tumors.

Fibrin binding peptide conjugates for diagnostic and therapeutic applications

The invention provides MRI detectable species of formula (I)D-S-N&#x2003;&#x2003;(I)wherein These compounds are useful for internalizing into tumor cells an amount of the MRI detectable moiety that is distinguishably higher than the amount internalized in normal healthy cells thus allowing the diagnosis of tumors. The internalization of the MRI detectable moiety involves the nutrients or pseudo-nutrients transporting system. Preferred compounds of formula (I) are those wherein D is the chelated complex of a paramagnetic metal ion.

Agents for magnetic imaging method

The invention relates to a one-step process for the preparation of aqueous solutions of hyperpolarized molecules in which, in a single step, the said hyperpolarized molecules are separated from the crude solution by means of a fast phase-transfer extraction and isolated in an impurity-free aqueous solution, ready for use in the MRI diagnostic imaging of organs, region or tissues of the human or animal body.

Process for the preparation of aqueous solutions of hyperpolarized molecules

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Carignano, Italy

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