Fondazione Istituto Italiano Di Tecnologia

Riken Corporation

Scuola Internazionale Superiore Di Studi Avanzati

International School for Advanced Studies

Transine Therapeutics Limited

Silvia Zucchelli

Stefano Gustincich

Piero Carninci

Alistair Forrest

Claudia Carrieri

Janez Plavec

Hazuki Takahashi

Toshio Yamazaki

Takako Ohyama

Harshita Sharma

Peter Podbevsek

There are disclosed functional nucleic acid molecules comprising a target binding sequence comprising a sequence reverse complementary to a target mRNA sequence for which protein translation is to be enhanced; and a regulatory sequence having two-dimensional structures comprising specific stem-loop and internal loop domains and displaying translation enhancing efficiency.

Structural domains of antisense RNA molecules up-regulating translation

There is disclosed a trans-acting functional nucleic acid molecule comprising a eukaryotic target binding sequence comprising a sequence reverse complementary to a target mRNA sequence for which protein translation is to be enhanced, and a regulatory sequence comprising an internal ribosome entry site (IRES) sequence or an internal ribosome entry site (IRES) derived sequence and enhancing translation of the target mRNA sequence, wherein the regulatory sequence is located 3' of the target binding sequence.

Functional nucleic acid molecule and use thereof

The present invention provides (a) a functional nucleic acid molecule comprises: a target determinant sequence comprising antisense sequence to a target sequence in the protein-encoding RNA for which protein synthesis efficiency is to be increased and a regulatory sequence having an activity of increasing of the protein synthesis efficiency, and (b) a use of the functional nucleic acid molecule.

Growing community of inventors

Trieste, Italy

Silvia Zucchelli