Merck Sharp + Dohme Corp.

Nicox S.a.

Nicox

Nicox Science Ireland

Silvia Stefanini

Nicoletta Almirante

Amjad Ali

Michael Man-Chu Lo

Stefano Biondi

Ennio Ongini

Iyassu Sebhat

Laura Storoni

Christopher L Franklin

Chris Franklin

Ravi P Nargund

Fabio Nicoli

Julio Lazaro Padron

Iyassu K Sebhat

A compound having the structure wherein R is, for example, Y is selected from the group consisting of 1) R5, 2) &#x2014;C(R1R2) (C(R3R4))0-1Y1R5, and 3) &#x2014;C(R1R2)&#x2014;O&#x2014;Y1R5; R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen and C1-4 alkyl; R5 is; Y1 is selected from the group consisting of C(O)&#x2014;O&#x2014; and P(O)(OR6)&#x2014;O&#x2014;; and R6 is hydrogen or CH3, or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension. 

Angiotensin II receptor antagonists

A compound having the structure wherein R is an angiotensin receptor antagonist active group, and Y is provided that when Y is &#x2014;C(O)(CH)R, then R is 

A compound having the structureR&#x2014;Y  

The invention relates to nitric oxide donors of the formula (I) and pharmaceutically acceptable salts or stereoisomers thereof: wherein A and A' are independently selected from the group consisting of H and &#x2014;(X)&#x2014;Y with the proviso that at least one of A or A&#x2032; is not H;wherein  The invention also provides novel compositions comprising at least one compound of the invention and at least one therapeutic agent.

Nitric oxide donor compounds

A compound having the structure wherein R is an angiotensin receptor antagonist active group, Y is -Y-Y-Y-Y-Y-; Yis C(RR); Ris selected from the group consisting of hydrogen and Calkyl; Ris selected from the group consisting of hydrogen, Calkyl, and &#x2014;OC(O)Calkyl; Yis O or CH; Yis C(O) or CH; Yis O or CH; Yis &#x2014;(CH)&#x2014;(X)&#x2014;(CH)&#x2014; or is absent; X is &#x2014;O&#x2014; or &#x2014;CRR&#x2014;; and Rand Rare independently selected from the group consisting of hydrogen and C-Calkyl; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.

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San Donato Milanese, Italy

Silvia Stefanini