Consejo Superior De Investigaciones Cientificas

Consiglio Nazionale Delle Ricerche

Universita Cattolica Del Sacro Cuore

Silvia Panseri

Anna Tampieri

Simone Sprio

Michele Iafisco

Monica Sandri

Jose Manuel Delgado Lopez

Jaime Gomez Morales

Raquel Fernandez Penas

Giandomenico Logroscino

Jaime GÓMEZ Morales

José Manuel Delgado LÓPEZ

Raquel FERNÁNDEZ Penas

Process for obtaining fluoride-doped citrate-coated amorphous calcium phosphate nanoparticles. This material has applications in biomedicine due to its biodegradability and bioactivity; it also promotes cell adhesion and osteogeneration. In dentistry, it may be used in toothpastes, mouthwashes, chewing gums, gels and fluoride varnishes as a remineralising agent of dentine and enamel. It is based on two solutions formed by calcium chloride and sodium citrate on the one hand, and by sodium monohydrogenophosphate and sodium carbonate with a fluoride compound on the other, which are mixed at room temperature. The process is eco-efficient and eco-friendly, as it does not leave any acid residue; it consists of a single stage and it is the first time that an amorphous calcium phosphate coated with citrate and doped with fluoride, which enhances its remineralising action, is obtained.

Process for obtaining fluoride-doped citrate-coated amorphous calcium phosphate nanoparticles

Growing community of inventors

Faenza, Italy

Silvia Panseri