Hoffmann-la Roche Inc.

Silvia Gatti Mcarthur

Matthias Heinrich Nettekoven

Olivier Roche

Rosa Maria Rodriguez-Sarmiento

Cornelia Hertel

Susanne Raab

Franz Schuler

Juergen Wichmann

Thomas Johannes Woltering

Jean-Marc Plancher

Erwin Goetschi

Hans G Richter

Wylie Solang Palmer

Theresa Maria Ballard

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

Naphthaline derivatives as H3 inverse agonists

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

Quinoline derivatives as H3R inverse agonists

The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R, R, and Rare as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.

Compounds as metabotropic glutamate receptor antagonists

The present invention relates to compounds of formula I: wherein X, R, R, R, Rand Rare as defined in the description and claims, and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

Indole derivatives as H3 inverse agonists

The present invention relates to compounds of formula (I): wherein Rto R, A, M, L, E, G, and J are as defined in the description and claims. The invention also relates to a process for the manufacture of such compounds, pharmaceutical compositions containing them, and methods for treating CNS disorders.

Acetylenyl-pyrazolo-pyrimidine derivatives

The present invention relates to a pharmaceutical composition comprising an inhibitor of acetylcholinesterase (AChE inhibitor) and a metabotropic glutamate receptor 2 antagonist (mGluR2 antagonist) and a pharmaceutically acceptable excipient. The invention also relates to a method of treating and/or preventing acute and/or chronic neurological disorders comprising administering to a patient in need of such treatment and/or prevention a therapeutically effective amount of said AChE inhibitor and mGluR2 antagonist as well as a kit comprising said AChE inhibitor and mGluR2 antagonist. In particular, the mGluR2 antagonist relates to the compound of formula I wherein, R, R, R, X and Y are described hereinabove. The combination of the AChE inhibitor and mGluR2 antagonist is useful for treating and/or preventing chronic neurological disorders. These disorders include Alzheimer's disease and mild cognitive impairment.

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Basel, Switzerland

Silvia Gatti Mcarthur