Advec, Inc.

Mcmaster University

Silvia Bacchetti

Frank L Graham

Michael A Rudnicki

Martina Anton

Ping Wang

William J Muller

Calvin B Harley

Christopher M Counter

Brian Leber

The invention claims a class of adenovirus vectors for delivering recombinases to a large number of cells of different origins, and methods for regulating the expression of a gene in transfected mammalian cells in culture and in cells of transgenic animals, comprising infecting said cells with an Ad vector encoding a recombinase whose target site is present at or adjacent to the gene, wherein the action of the recombinase regulates the expression of said gene.

Adenoviruses for control of gene expression

Methods for detecting hematologic and colorectal malignancies are provided comprising: (a) collecting a sample suspected of containing cancer cells; (b) analyzing the sample for telomerase activity; (c) correlating the presence of telomerase activity with the presence of cancer cells. A method for staging leukemia is also provided comprising analyzing a blood or bone marrow sample for telomerase activity, correlating the activity with a standard level of telomerase activity, and correlating a low telomerase activity with early stage leukemia.

Telomerase activity associated with hematological and colorectal

Growing community of inventors

Hamilton, Canada

Silvia Bacchetti