Boehringer Mannheim Italia

Boehringer Biochemia Robin S.p.a.

Hoffmann-la Roche Inc.

Virginia Commonwealth University

University of Vermont and State Agricultural College

F. Hoffmann-la Roche Ag

University of Vermont

Novus Pharma LLC

Clovis Oncology Italy S.r.l.

Boehringer Mannheim Gmbh

Eos Ethical Oncology S.p.a. Abbreviated Form Eos S.p.a.

Setanta Therapeutics, Inc.

Boehringer Mannhein Italia, S.p.a.

Silvano Spinelli

Ernesto Menta

Sergio Tognella

Carmelo A Gandolfi

Odoardo Tofanetti

Roberto Di Domenico

Valeria Livi

Nicholas P Farrell

Marco Frigerio

Ambrogio Oliva

Licia Gallico

Mariella Valsecchi

Bruno Lumachi

A Paul Krapcho

Carlo Bugatti

Alessandro Pasini

Roberto DiDomenico

Franco Zunino

Marco Conti

Carla Manzotti

Raimondo Russo

Simonetta D'Alo'

Hans-Willi Krell

Giorgio Long

Antonella Rozzi

Giovanni Da Re

Ferdinando C Giuliani

Paolo Pavesi

Fernando Giuliani

Enzo Alessio

Luisa Del Greco

PierVitto Cipolla

Daniele Castoldi

Sengio Tognella

Francis Johnson

Erneston Menta

Gianni Sava

Sabrina Pocar

Paul Krapcho

Giovanni Mestroni

A process for the preparation in high yields and purity of the compound 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.

Process for the preparation of 6-(7-((1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide and synthetic intermediates thereof

A process for the preparation in high yields and purity of the compound 6-(7-4(1-aminocyclopropyl)methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide of formula (I) and of the pharmaceutically acceptable salts thereof is described. The process has various advantages over those previously described, in particular it avoids the use of acyl azide intermediates and their Curtius rearrangement. Novel intermediates useful for the preparation of compound (I) are also described.

The present invention relates to tetra- and penta-nuclear platinum complexes with antitumor activity, to a method for preparing them and to pharmaceutical compositions containing them.

Multinuclear cationic platinum complexes with antitumor activity

The present invention relates to conjugates of 3-carboxy-4,4&prime;-dihydroxyphosphorylbutenoic acids with alkylating agents, derivatives are endowed with marked antitumor activity, especially against multiple myeloma. The present invention relates as well to a process for the preparation thereof and to pharmaceutical compositions containing them.

Bis-phosphonate confugates with alkylating moieties having antitumor activity

Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents

Bis-platinum complexes with polymethylene derivatives as ligands having

2-[2-[(2-hydroxyethyl)amino]ethy                                         [

Bis-platinum complexes with polyamine ligands as antitumor agents

Trinuclear cationic platinum complexes having antitumor activity and

In the search for novel heteroanalogs of anthracendiones, 6,9-bis�(2-aminoethyl)amino!benzo�g!isoquinoline-5,10-dione dimaleate salt (BBR 2778), was selected as the most promising compound. New methods of synthesis produce the compound in purity greater than 99%.

Method of synthesis for

In the search for novel heteroanalogs of anthracendiones, 6,9-bis[(2-aminoethyl)amino]benzo[g]isoquinoline-5,10-dione dimaleate salt (BBR 2778), was selected as the most promising compound. New methods of synthesis produce the compound in purity greater than 99%.

1,4-disubstituted piperazines useful in the therapy of the asthma and of

This invention is directed to 2-aminoalkyl-5-aminoalkylamino substituted isoquino[8,7,6-cd]indazole-6-(2H)-ones and to 2-aminoalkyl-5-aminoalkylamino substituted-isoquino[5,6,7-cd]indazole-6(2H)-ones. These compounds have been shown to have antitumor activity.

2-aminoalkyl-5-aminoalkylamino substituted-isoquinoindazole-6(2H)-ones

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Milan, Italy

Silvano Spinelli