Lifegroup S.p.a.

Fidia S.p.a.

Silvana Lorenzi

Francesco Della Valle

Aurelio Romeo

Gabriele Marcolongo

Lanfranco Callegaro

Alberta Leon

Federica Della Valle

Gabriella Calderini

Roberto Cerini

Lauro Galzigna

Jacobus C Samson

Therapeutic use of mono and bicarboxylic acid amides active at the

Use of N-acyl derivatives of aminoalcohols in the manufacture of a

Highly bioadhesive and mucoadhesive compositions containing polyvinyl

Described herein are biotin amides which are able to control glucidic metabolism under dysmetabolic conditions and relative therapeutical compositions for the treatment of insulin-independent diabetes, insulin-dependent diabetes and relative complicating diseases, such as peripheral neuropathies and other associated chronic invalidating disorders.

Biotin amides able to control glucidic metabolisms under dysmetabolic

Aminoalcohols N-acyl derivatives useful in the prevention and in the treatment of mammalian pathologies induced by mast cell degranulation in consequence of peripheral nerve noxae.

Aminoalcohols-N-Acyl derivatives as therapeutical agents against the

Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intraarticular injections. In addition, pharmaceutical preparations for topical administration are provided containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.

Pharmaceutical compositions containing hyaluronic acid fractions

N-acyl derivatives of aminoalcohols with bicarboxylic or tricarboxylic acids able to modulate the degranulation process consequent to the mast cells activation in inflammatory processes caused by supramaximal stimuli of neurogenic and immunogenic origin.

N-acyl derivatives of aminoalcohols with polycarboxylic acids able to

Traumatic acid salts, wherein B is a cation selected from:

Trans and cis traumatic acid salts having cicatrizant activity

A highly pure fraction of hyaluronic acid is disclosed which is non-inflammatory and avoids post-operative complications in ocular surgery. Also disclosed is a process for the preparation of hyaluronic acid characterized by converting hyaluronic acid into a corresponding quaternary ammonium salt and, following purification procedures, reconverting the quaternary ammonium salt into a sodium salt of hyaluronic acid.

Procedure for the purification of hyaluronic acid and fraction of pure

Salts of biotin are described with alkanolamines and the respective water soluble therapeutical compositions, suitable to be orally, parenterally and topically administered. The compositions above are particularly suitable for the treatment of the vitamin H deficiency, having a dermatologic manifestation, for the treatment of the insufficiency in multiple carboxylase enzymes, for the treatment of dermatologic phatologies, like the seborrheal dermatitis in the newborn, and for the treatment of diabetic neuropathies.

Water soluble derivatives of biotin and related therapeutical

The process of the invention relates to a process for the preparation of a ganglioside mixture, free from contaminants associated with non-conventional, life-threatening viruses, without altering the biological and pharmacological characteristics of the mixture on the central and peripheral nervous systems.

Method for the preparation and purification of a mixture of

N-acyl-derivatives of hydroxyamines suitable for the therapeutic treatment of pathologies characterized by degranulation of mast cells caused by a neurogenic and/or immunogenic hyperstimulation.

N-acyl derivatives of aminoalcohols active as local autacoids and useful

Hydroxyamines N-acyl derivatives with benzochroman or 2,3-dihydrobenzofuran carboxy acids and relative pharmaceutical composition for the therapeutic treatment of those CNS, vascular, cardiovascular, dermatologic and ophthalmic pathologies wherein it is important to associate an inflammatory modulation effect to an antioxidant activity.

Hydroxyamines N-acyl derivatives having scavenger activity and useful in

Salts and mixtures of hyaluronic acid with pharmaceutically active

The present invention is directed to a method for the isolation of Human Nerve Growth Factor (HNGF) from human placenta. More particularly, the invention is directed to the method of isolation of the .beta.-subunit of Human Nerve Growth Factor and Compositions containing the same for the treatment of neuropathological conditions.

Growing community of inventors

Padova, Italy

Silvana Lorenzi