The Medicines Company (leipzig) Gmbh

The Medicines Company

Silke Nicklisch

Torsten Steinmetzer

Andrea Schweinitz

Claudia Reichelt

Alexander Schulze

Friedrich-Alexander Ludwig

Joerg Stuerzebecher

Jochen Heinicke

Peter Steinmetzer

Andreas Van De Locht

Mohammed Daghish

Jörg Stürzebecher

Anett Soeffing

Mohammed Daghisch

Anett Söffing

The invention relates to inhibitors of trypsin-like serine proteases, including those of the general formula (IV) which, as well as plasmin, also inhibit plasma kallikrien, and to their use as medicaments, preferably for treatment of blood loss, especially in the case of hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive.

Trypsin-like serine protease inhibitors, and their preparation and use

The invention relates to inhibitors of trypsin-like serine proteases of the general formula (I) which, as well as plasmin, also inhibit plasma kallikrein, and to their preparation and use as medicaments, preferably for treatment of blood loss, especially in the case of hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive.

The invention relates to inhibitors of trypsin-like serine proteases of the general formula (I) which, as well as plasmin, also inhibit plasma kallikrien, and to their preparation and use as medicaments, preferably for treatment of blood loss, especially in the case of hyperfibrinolytic states, in organ transplants or heart surgery interventions, in particular with a cardiopulmonary bypass, or as a constituent of a fibrin adhesive.

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Leipzig, Germany

Silke Nicklisch