Evonik Degussa Gmbh

Evonik Operations Gmbh

Silke Jerrentrup

Brigitte Bathe

Georg Thierbach

Caroline Kreutzer

Wilfried Claes

Frank Jankowitsch

Kornelia Voß

Iris WIEGRÄBE

strains express modified gluconate repressor proteins GntR1 and GntR2. Thestrains have an increased ability to produce L-lysine compared with an ability of a wildtype strain. The gluconate repressor protein GntR1 includes an amino acid sequence of SEQ ID NO: 9, where the amino acid Arg in position 102 is replaced by the amino acid Glu. The gluconate repressor protein GntR2 includes SEQ ID NO: 10, and its activity is attenuated compared to the activity of the GntR2 repressor protein of the wild-type strain. A method is developed for the fermentative production of L-lysine using suchstrains.

Method for the fermentative production of L-lysine usingstrains expressing modified gluconate repressor proteins GntR1 and GntR2

The invention relates to mutants and alleles of the oxyR gene of coryneform bacteria coding for variants of the OxyR transcription regulator and processes for producing amino acids using bacteria which comprise these alleles.

Alleles of the oxyR gene from coryneform bacteria

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Bielefeld, Germany

Silke Jerrentrup