Biotest Ag

Immunogen, Inc.

Dana-farber-cancer Institute Inc.

Silke Aigner

Benjamin Daelken

Frank Osterroth

Christoph Bruecher

Christoph Uherek

Matthias Germer

Gregor Schulz

Elmar Kraus

Andrea Wartenberg-Demand

Steffen Zeng

Daniele Wolf

Sibylle Kaiser

Juergen Lindner

Thomas Haeder

Kenneth Carl Anderson

Teru Hideshima

Chantal Zuber

Niklas Czeloth

Gabriele Niemann

Markus Ruehle

Michael Soldan

Anatoly Rudnev

The present invention provides pharmaceutical composition for treating an autoimmune disease comprising a pharmaceutically acceptable carrier and an agent capable of activating CD4+CD25+ regulatory T cells, wherein the composition is to be administered to a subject at most every 3 days.

Method for treating psoriasis

The present invention provides a pharmaceutical composition for treating an autoimmune disease comprising a pharmaceutically acceptable carrier and an agent capable of activating CD4+CD25+ regulatory T cells, wherein the composition is to be administered to a subject in a dose of the agent from 10 mg to 200 mg.

Agent for treating disease

Disclosed are immunoconjugates having specificity for CD138 that diminish adhesion of CD138 expressing tumor cells to stroma cells and methods of using the same. This diminished adhesion renders the tumor cells not only susceptible to the immunoconjugate, but also to other agents, in particular cytotoxic agents.

Methods and agents for improving targeting of CD138 expressing tumor cells

Disclosed are immunoconjugates having in particular specificity for CD138 expressed on target cells and which display homogenous targeting. The immunoconjugates may be sterially hindered and/or contain a cleavable linker.

Immunoconjugates targeting CD138 and uses thereof

The present invention provides a pharmaceutical composition for treating an autoimmune disease comprising a pharmaceutically acceptable carrier and an agent capable of activating CD4+CD25+ regulatory T cells, wherein the composition is to be administered to a subject in a dose of the agent from 0.2 mg to 30 mg.

Disclosed are methods and treatment regimes that include the administration of immunconjugates targeting CD138 to combat diseases. The immunoconjugate is either used as the sole active ingredient, as part of a treatment regime or as part of an anticancer combination.

Uses of immunoconjugates targeting CD138

Disclosed is a human murine chimeric antibody targeting CD138 which substantially retains the antigen binding region of its murine counterpart. The engineered antibody displays improved binding affinities to the antigen and/or more homogenous binding to target cells relative to its murine counterpart. A constant region of the immunoglobulin heavy chain is preferably an IgG4 isotype constant region.

Agents targeting CD138 and uses thereof

Disclosed are methods, compositions and kits for improving targeting, in particular tumor targeting, of immunoconjugates. The method and composition relies on the sequestration of non-target cells that also express the antigen the immunoconjugate targets. Sequestration of those non-target cells in a variety of ways is disclosed. The methods, compositions and kits allow appropriate sequestration of non-target cells while maintaining a high degree of effectiveness of the immunoconjugates against target cells.

Method of decreasing cytotoxic side-effects and improving efficacy of  immunoconjugates

Growing community of inventors

Frankenthal, Germany

Silke Aigner