Societe Civile Bioprojet

Heumann Pharma Gmbh & Co.

Societe Civile Bioproject

Sigurd Elz

Charon R Ganellin

Jean-Charles Schwartz

Xavier Ligneau

Walter Schunack

Jean-Michel Arrang

Monique Garbarg

Fabien Leurquin

Jeanne-Marie Lecomte

Holger Stark

Helmut Schickaneder

Istvan Szelenyi

Kurt H Ahrens

Armin Buschauer

Gert Baumann

Jeanne-Marie Lecounte

Walter G Schunacx

Hulger Stark

Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H-receptors when attached to an imidazole ring in 4(5) position; Rand Rmay be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H-receptors of histamine.

[object Object]

Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H-receptors when attached to an imidazole ring in 4(5) position; Rand Rmay be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H-receptors of histamine 

New imidazolylalkyl-guanidine derivatives are described, which by virtue of their agonistic action on histamine-H.sub.2 receptors and in part also due to their additional H.sub.1 -antagonistic receptor activity can be used in the treatment of cardiac diseases, certain forms of hypertension and diseases of arterial occlusion. These imidazolylalkyl-guanidine derivatives correspond to the general formula I: ##STR1##

Imidazolyl alkyl guanidine derivatives, processes for their preparation

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Berlin, Germany

Sigurd Elz