Micronas Gmbh

Biocer Entwicklungs Gmbh

Sigrun Herrmann

Helmar B Mayr

G&uuml;nter Igel

Daniel Seitz

Guenter Ziegler

Winfried Vonau

Frank Gerlach

Heiner Kaden

Wolfram Oelssner

The invention relates to an arrangement (a measurement device) for on-line measurements on cells, in particular for measuring soluble analytes and dissolved gases on samples in a sample area. The object of the invention, to specify an arrangement for on-line measurements in order to investigate and monitor the metabolism of living cells, which avoids the disadvantages of the prior art and can be integrated in a microfluidic system in the process, is achieved in that the arrangement comprises a substrate, at least one sensor, a sample analysis space and a membrane with the substrate holding the sensor or the sensors and the membrane in such a way that the sample analysis space is generated between the sensor or sensors and the membrane, with the membrane having the capability to be connected in a biocompatible form and to a cell culture space with the sensor or sensors being electrochemical sensors, and in which the sample analysis space can be filled with a transfer medium and can be integrated in fluidic systems, and the sensor sensors is or are fitted with operating circuits via which downstream electronics can be coupled.

Arrangement for on-line measurements on cells

A reference electrode ( ) for electrochemical measurements includes a metallic palladium-containing electrode component ( ) which is covered by a layer ( ) formed of or containing a palladium compound poorly soluble in aqueous media. Positioned on layer ( ) is a reference electrolyte ( ) which contains anions of this palladium compound in dissolved form (FIG. ).

Reference electrode

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Waldheim, Germany

Sigrun Herrmann