General Electric Company

Nycomed Imaging As

Amersham Health As

Ge Healthcare As

Nyomed Imaging As

Sigmund Frigstad

Morten Eriksen

Jonny &Oslash;stensen

P&aring;l Rongved

Lars Hoff

Hans Garmann Torp

Audun Tornes

Nils Sponheim

Knut Dyrstad

Jo Klaveness

Harald Dugstad

Svein Arne Aase

Pål Rongved

Stein Inge Rabben

Jean-Francois Gelly

Abhijit Vishwas Patil

Roald Skurtveit

Mahesh Raveendranatha Panicker

Anders Herman Torp

Sevald Berg

Jonny O Slashedstensen

Srinivas Varna

Pavan Kumar V Annangi

Jonny Ostensen

Jorunn Brænden

David Johnson

Jonny Østensen

Morton Eriksen

In an embodiment of the subject matter described herein a system is provided. The system includes a portable host system having one or more processors and a memory for storing a plurality of applications. The one or more processors configured to execute programmed instructions of a select application by performing one or more operations, which include obtain a set of frames of 2D ultrasound images, develop a prospect model indicating a likelihood that frames within the set include an organ of interest (OOI), identify primary and secondary reference frames from the set of the frames based on the prospect model, determine a characteristic of interest in the primary reference frame, select a candidate shape for the OOI based on the character of interest in the primary reference frame, and adjust the candidate shape based on the secondary reference frames to form a resultant shape for the OOI.

Method and system for measuring a volume of an organ of interest

An acquisition component is provided that includes an audible sound sensor configured to receive audible sounds within a sensing area and a multi-element ultrasound transducer configured to emit ultrasound signals and to receive reflections of the ultrasound signals in the same sensing area. The audible sound sensor and the multi-element ultrasound transducer may be configured to be simultaneously operable.

Methods and apparatus for combined audible and ultrasound inspection of objects, including patients

Ultrasound contrast agents comprising microbubbles of biocompatible gas, e.g. a sulphur halide or a perfluorocarbon, stabilized by opsonisable amphiphilic material, e.g. a membrane-forming lipid such as a phospholipid, especially a negatively charged phospholipid such as a phosphatidylserine, may exhibit prolonged contrast-generating residence time in the liver following intravenous administration.

Contrast agents

A method and system for multiple view volume rendering are provided. The method includes identifying a plurality of view directions relative to an image of an object and automatically volume rendering a volumetric data set based on the plurality of view directions. The method further includes generating an image for each view direction using the rendered data.

Method and system for multiple view volume rendering

A method and apparatus for detecting cardiac events. Ultrasonic data comprising a heart cycle is acquired by a probe. Tissue velocities associated with the ultrasonic data are detected. One of a maximum and a minimum value is detected based on the tissue velocities. A time within the heart cycle associated with the maximum or minimum value is determined, and a cardiac event is detected with respect to the time within the heart cycle and the maximum or minimum value.

Method and apparatus for detecting cardiac events

A combined preparation comprising: i) an ultrasound contrast agent capable of accumulation in tissue microvasculature; and ii) a pharamacologically effective amount of a vasodilator drug may be used in perfusion imaging, especially of the myocardium. The contrast agent accumulates in tissue in concentrations related to the regional rate of tissue perfusion, and the vasodilator drug enhances distinction between normally perfused and underperfused tissue.

Ultrasound imaging with contrast agent targeted to microvasculature and a vasodilator drug

Ultrasonic visualisation of a suject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations include a coadministerable composition comprising a diffusible component capable of inward diffusion into the dispersed gas phase to promote temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences in return signal intensity from normal and hypoperfused myocardial tissue respectively.

Ultrasound imaging using gas microbubble-containing contrast agents may be performed in the recirculating phase following admixture of the contrast agent with the blood pool, thereby prolonging the useful imaging time window compared to that conventionally obtained during the backscatter signal peak resulting from first pass of a contrast agent bolus. The length of the time window may further be increased by imaging at ultrasound frequencies of 2 MHz or less, particularly by harmonic imaging at transmit frequencies less than the resonance frequencies of the gas microbubbles.

In or relating to contrast agents

Local aberrations in the perfusion and/or compliance of vasculated tissue may be detected by contrast agent-enhanced ultrasound imaging procedures wherein a sequence of ultrasound image data is generated in respect of a region of interest in vasculated tissue, the image data is processed to generate waveforms representative of arterial pulsatility, and these waveforms are analyzed for variations such as phase distortions which are characteristic of local aberrations in tissue perfusion and/or compliance.

Ultrasonography

Ultrasonic visualization of a subject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations include a coadministerable composition comprising a diffusible component capable of inward diffusion into the dispersed gas phase to promote temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences in return signal intensity from normal and hypoperfused myocardial tissue respectively.

A method of measuring tissue perfusion in a human or non-human animal subject which comprises administering an effective amount of an ultrasound contrast agent to said subject, irradiating tissue in a target region with at least one pulse of ultrasound having energy sufficient to destroy or discernibly modify the echogenic properties of substantially all contrast agent in said target region, and ultrasonically detecting and quantifying the rate of flow of either further contrast agent into said target region or modified contrast agent out of said target region.

Ultrasound imaging of tissue perfusion by pulse energy disruption of contrast agent

Temporal variations in backscatter from an ultrasound contrast agent located in the vascular system and induced by movement of the scatterers are used to visualize the presence of contrast agent by determining areas where correlation between successive ultrasound images is poor. This low level of correlation from intravascular contrast agent movement permits distinction between stationary bulk tissue and moving bulk tissue since movement of the latter solid tissue scatterers is correlated.

Ultrasound imaging

Temporal variations in backscatter from an ultrasound contrast agent located in the vascular system and induced by movement of the scatterers are used to visualise the presence of contrast agent by determining areas where correlation between successive ultrasound images is poor. This low level of correlation arising from intravascular contrast agent movement permits distinction between stationary bulk tissue and moving bulk tissue since movement of the latter solid tissue scatterers is correlated.

Growing community of inventors

Trondheim, Norway

Sigmund Frigstad