Otsuka Kagaku Kabushiki Kaisha

Otsuka Kagaku Yakuhin Kabushiki Kaisha

Taiho Pharmaceutical Company Limited

Ouchi Shinko Kagaku Kogyo Kabushiki Kaisha

Kuraray Co., Ltd.

The Institute of Creative Chemistry Co., Ltd.

Otsuka Kagaku Yakuhim Kabushiki Kaisha

Otsuke Kagaku Yakuhin Kabushiki Kaisha

Sigeru Torii

Hideo Tanaka

Michio Sasaoka

Takashi Shiroi

Yutaka Kameyama

Norio Saito

Junzo Nokami

Masatoshi Taniguchi

Motoaki Tanaka

Shozo Yamada

Yuichi Kobayashi

Akira Nakai

Kenji Uneyama

Ryo Kikuchi

Shigemitsu Nagao

Seiryu Uto

Hisashi Ohbayashi

Isao Wada

Akira Tanaka

Takashi Siroi

Masashi Ukida

Kiyoshi Mishima

Yasuhisa Amano

Takashi Nishida

Yoshiji Fujita

Takashi Onishi

Daisuke Suzuki

Michihiro Ishiguro

Mitsuo Akada

Yoshihisa Tokumaru

Yuzuru Ogata

Kiyotoshi Matsumura

Tomoyasu Ohno

Syozo Hayase

Kouichi Miki

Toshihiro Kudai

A method of recovering a liquid medium from a mixture containing the liquid medium, the method including: (a) blowing a first gas into the mixture containing the liquid medium to vaporize the liquid medium, in a first vaporizing means, thereby to form a second gas containing which is a mixture of the first gas and vaporized liquid medium; (b) continuously dropwise feeding the mixture containing the liquid medium into a second vaporizing means and counter-flowingly contacting the mixture containing the liquid medium, with the second gas to vaporize additional liquid medium to form a third gas which is a mixture of the second gas and additional vaporized liquid medium; and (c) feeding the third gas into a condensing means to condense the vaporized liquid medium into a liquid and separate the first gas, which is then blown into the first vaporizing means in step (a).

Method for recovering a liquid medium and system for recover a liquid medium

The present invention is directed to a process for preparing an exo-methylenepenam compound wherein a cephem compound is reduced with a metal having a standard oxidation-reduction potential of up to &minus;0.3 (V/SCE) in an amount of at least one mole per mole of the cephem compound and with a metal compound having a higher standard oxidation reduction potential than the metal and in an amount of 0.001 to 10 moles per mole of the cephem compound and wherein X is a halogen atom, lower alkylsulfonyloxy, trifluoromethanesulfonyloxy, trichloromethanesulfonyloxy, arylsulfonyloxy, toluenesulfonyloxy, or halogenated sulfonyloxy

Process for producing exo-methylenepenam compounds

The present invention provides a process for preparing an exo-methylenepenam compound represented by the general formula (5) characterized in that a &bgr;-lactam halide compound represented by the general formula (2) is subjected to an electroreduction process to obtain the exo-methylenepenam compound.

Process for preparing beta lactam compound

A process for preparing an allenyl .beta.-lactam compound represented by the formula (4), characterized by reacting the hydroxyl group of a .beta.-lactam compound represented by the formula (1) with a reactive functional group derivative of sulfonic acid represented by the formula (2) to convert the compound of the formula (1) to a .beta.-lactam compound represented by the formula (3), thereafter reacting the resulting .beta.-lactam compound with a basic anion exchange resin of the type having a tertiary organic base fixed to the resin and isolating the resulting allenyl .beta.-lactam compound of the formula (4) from the reaction mixture ##STR1##

Process for preparing .beta.-lactam derivatives

The present invention provides a process for preparing an exo-methylenepenam compound represented by the general formula (5) characterized in that a .beta.-lactam halide compound represented by the general formula (2) is reduced with a metal having a standard oxidation-reduction potential of up to -0.3 (V/SCE) in an amount of at least one mole per mole of the halide compound and with a metal compound having a higher standard oxidation-reduction potential than the metal in an amount of 0.0001 to 10 moles per mole of the halide compound, or is subjected to an electroreduction process to obtain the exo-methylenepenam compound. ##STR1##

Process for preparing .beta.-lactam compound

Process for preparing .beta.-lactam halide compound

Process for preparation of .beta.-lactam compounds

Process for preparing 3-norcephem compounds

Process for preparing 3-alkoxymethylcephem compounds

Cyclization for preparing halo-cephems

The present invention provides a thiazolinoazetidinone derivative represented by the formula ##STR1## wherein R.sup.1 is phenyl having or not having substituent(s), methyl having or not having substituent(s) or ##STR2## group, R.sup.3 being phenyl having or not having substituent(s), and R.sup.2 is a hydrogen atom or carboxylic acid protective group, and a process for preparing the same. The present invention further provides a process for preparing a 2-exo-methylenepenam derivative characterized by hydrolyzing the thiazoline ring of a thiazolinoazetidinone derivative of the above formula (1) to effect recyclization and obtain a 2-exo-methylenepenam derivative represented by the formula ##STR3## wherein R.sup.1 and R.sup.2 are as defined above.

Process for preparing thiazolino azetidinone and 2-exo-methylenepenam

Thiazolinoazetidinone derivative

The present invention provides a process for preparing a cephem derivative characterized in that an allenyl .beta.-lactam compound represented by the formula (1) ##STR1## wherein R.sup.1 is amino or protected amino, R.sup.2 is a hydrogen atom or lower alkoxyl, R.sup.3 is a hydrogen atom or carboxylic acid protecting group and X is the group --SO.sub.2 R.sup.4 or --SR.sup.4, R.sup.4 being substituted or unsubstituted aryl or substituted or unsubstituted nitrogen-containing aromatic heterocyclic group is reacted with a nucleophilic agent to obtain the derivative, the cephem derivative being represented by the formula (2) ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above, and Y is the residue of the nucleophilic agent.

Process for preparing cephem derivatives

The present invention provides a process for preparing a 2-exo-methylenepenam derivative represented by the formula (2), the process being characterized by reacting an allenyl .beta.-lactum compound represented by the formula (1) with a metallic reducing agent, in which R.sup.1, R.sup.2, R.sup.3 and X are defined in the specification. ##STR1##

Process for preparing 2-exo-methylenepenam derivatives

Growing community of inventors

Okayama, Japan

Sigeru Torii