Nanyang Technological University

Agency for Science, Technology and Research

National Skin Center (s) Pte Ltd

Sierin Lim

Sarker Mridul

Steven Thng

Sathyamoorthy Bhaskar

Ambili Kuniyil

Nikodem Tomczak

Fok Moon Lum

Kang Yu

Chengxun Su

Fong Poh Lisa Ng

David Paramelle

Yiu-Wing Jason Kam

Paul Free

Wei Ling Wendy Lee

Tao Peng

The present invention relates to protein nanocages comprising a melanocyte-targeting moiety and pharmaceutical compositions comprising the protein cages as well as methods for treating or diagnosing hyperpigmentation disorders or other melanocyte-related disorders using the protein nanocages or pharmaceutical compositions.

Targeting of melanocytes for delivering therapeutic or diagnostic agents using protein nanocages

The present invention relates to protein nanocages comprising a melanocyte-targeting moiety and pharmaceutical compositions comprising the protein cages as well as methods for treating or diagnosing hyperpigmentation disorders or other melanocyte-related disorders using the protein nanocages or pharmaceutical compositions. In the preferred embodiment, the protein nanocage is composed ofE2 protein of pyruvate dehydrogenase multi-enzyme complex (E2), with a skin penetrating and cell permeating SPACE moiety, and a melanocyte-targeting moiety of alpha melanocyte stimulating hormone.

The present invention refers to a composition comprising a viral protein or fragment thereof, wherein the viral protein or fragment thereof is enclosed within a self-assembling protein nanocapsule, preferably ferritin, and wherein the viral protein, or fragment thereof is selected from a virus of the Togaviridae family. The viral protein or fragment thereof may also further be selected from a virus of the alphavirus subfamily.

Nanocapsules carrying chikungunya-associated peptides

The invention relates to a method to encapsulate nanoparticles into a protein cage by inserting the nanoparticles into the core through holes. Currently commercially available nanoparticles can be functionalized using the inventive method. The inventive hybrids have applications in biosensing and bioimaging. The use of an affinity between poly-histidine chains and nitrilotriacetic acid as chelating reagent to obtain the inventive cages and hybrid assemblies by the method according to the invention is shown in FIG.

Specific internalization of nanoparticles into protein cages

Growing community of inventors

Singapore, Singapore

Sierin Lim