Novartis Ag

Siem Jacob Veenstra

Gottfried Sedelmeier

Rainer Machauer

Marina Tintelnot-Blomley

Heinrich Rueeger

Rainer Martin Lueoend

Konstanze Hurth

Markus Voegtle

Sangamesh Badiger

Murali Chebrolu

Sebastien Jacquier

Yves Auberson

Claudia Betschart

Hans Allgeier

Thomas Josef Troxler

Silvio Ofner

Kurt Laumen

Pierre Acklin

Ralf Glatthar

Stefanie Flohr

Clive McCarthy

Jean-Michel Rene Rondeau

Oliver Simic

Olivier Rogel

Michel Biollaz

Manuel Koller

Henrik Moebitz

Eric Vangrevelinghe

Robert Moretti

Andreas Lerchner

Emmanuelle Briard

Janos Zergenyi

Sébastien Jacquier

Kurt Nebel

The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.

Heterocyclic derivatives and their use in the treatment of neurological disorders

The invention relates to novel oxazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2. 

Oxazine derivatives and their use in the treatment of disease

The invention relates to novel oxazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.

The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.

Oxazine derivatives and their use in the treatment of neurological disorders

The invention relates to a method of administering N-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-4-(quinoloylamino)-piperidines of the formula wherein Y is &#x2550;N&#x2014; or &#x2550;N(O)&#x2014;, R is OH when Y is &#x2550;N&#x2014; and R is H when Y is &#x2550;N(O)&#x2014; and the ring A is unsubstituted or mono- or poly-substituted by substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl, provided that when R is OH and Y is &#x2550;N&#x2014; the ring A is not unsubstituted, for the treatment of disorders induced by substance P, such as: pain, migraines, anxiety, vomiting, schizophrenia, depression; motor disorders such as Parkinson's disease, inflammatory diseases such a rheumatoid arthritis, iritis and conjunctivitis, diseases of the respiratory organs such as asthma and chronic bronchitis, diseases of the gastrointestinal system such as ulcerative colitis and Crohn's disease, and hypertension.

Aroyl-piperidine derivatives and method of treating disorders induced by substance P

The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.

Cyclic sulfones with aminobenzyl substitution useful as BACE inhibitors

The invention relates to novel macrocyclic compounds of the formula in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.

Macrocyclic compounds useful as BACE inhibitors

The invention relates to novel N-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-4-(quinoloy-lamino)-piperidines of the formula . . . wherein Y and R each are as defined above and the ring A is unsubstituted or mono- or polysubstituted by substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl; and the salts thereof, to the use thereof, to processes for the preparation thereof and to pharmaceutical compositions comprising a compound according to the invention. 

Aroyl-piperidine derivatives

The present invention pertains to novel dibenzo[b,f]oxepine-10-carboxamides compound to a process for the preparation of such compounds of formula I, their use as a pharmaceuticals, especially in the treatment of neurological and vascular disorders related to beta-amyloid generation and/or aggregation, and to pharmaceutical compositions and combinations comprising such compounds of formula I.

Dibenzo[b,f]oxepine-10-carboxamides and pharmaceutical uses thereof

The present invention relates to novel macrocyclic compounds of the formula wherein R, R, R, U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.

Macrocyclic lactams and pharmaceutical use thereof

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Lorrach, Germany

Siem Jacob Veenstra