Koninklijke Philips Corporation N.V.

Biocartis, Nv

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Roel Penterman

Paul Arnold Van De Wiel

Marc Wilhelmus Gijsbert Ponjee

Kristiane Anne Schmidt

Oana Mihaela Piciu

Ron Gill

Rieko Verhagen

Reinhold Wimberger-Friedl

Ruud Vlutters

Anke Pierik

Bart Gottenbos

Bas Hulsken

Jozef Johannes Maria Janssen

Jelte Peter Vink

Robbert Adrianus Maria Van Hal

Dirk Brokken

Paul Anton Josef Ackermans

Francisco Morales Serrano

Guido Roosen

Bart Van Meerbergen

Paul A J Ackermans

Zeynep Seflek Unay

Irene Dobbelaer

Zeynep Seflek

Bart Edward Gusta Jozef Van Meerbergen

Bart Edward Jozef Gusta Van Meerbergen

Robbert A M Van Hal

Jozef J M Janssen

Bart Edward Van Meerbergen

Marc Wilhelmus Ponjee

Methods and devices for detection of micro-organisms present or suspected to be present within a mammalian blood sample are provided. A selective lysis is obtained by incubating the sample in a non-ionic detergent under alkaline conditions.

Selective lysis of cells

The present invention relates to an illustration of an annotation () at a sample slide (). It is the intention for the invention to copy the annotation () provided at a reference slide () to the sample slide (). Typically, a reference image () of the reference slide () is provided, in particular by scanning the reference slide (). The reference image () therefore has the information about a reference slice () which is carried by the reference slide (). Furthermore, the reference slide () has been marked with a region of interest () and the annotation (), which can be associated with the region of interest (). If such reference slide () is scanned, the respective reference image () comprises the information about the marked region of interest () as well as the annotation (), too. Furthermore, the sample slide () carrying a sample slice () can be scanned, in order to provide a sample image (). The sample slice () and the reference slice () are cut from the same object () of a biological material. In particular, the sample slice () has been cut directly after a cut of a material block has been preformed to provide the reference slice (). Since the reference slice () and the sample slice () are from the same object (), their features are very likely that the reference image () and the sample image () are very similar. Due to this similarity, the annotation () of the reference slide () is copied on a basis of an image recognition between reference image () and the sample image () to the sample slide ().

Information transformation in digital pathology

Methods and devices for the selective lysis of cells in a sample comprising micro-organisms such as bacteria are provided. The selective lysis is obtained by incubating the sample in a non-ionic detergent under alkaline conditions.

The present invention discloses methods, kits-of-parts, and devices for the selective lysis of eukaryotic cells in a sample comprising micro-organisms such as bacteria unicellular fungi. The selective lysis is obtained by incubating the sample in an ionic surfactant under alkaline conditions.

Selective lysis of cells by ionic surfactants

The invention provides a skin treatment device comprising a laser source () and focusing optics (), such that a focal spot () is positioned in a dermis layer () of the skin to be treated. The laser beam () is powered and focused () such that a LIOB (laser induced optical breakdown) phenomenon is obtained, which affects the skin in order to stimulate re-growth of tissue. This in turn reduces wrinkles (). The device may comprise wrinkle-determining means (). The focusing optics () may have a numerical aperture of at least 0.4. The invention also provides a corresponding method to treat skin, in particular to reduce wrinkles (), by providing a focused laser beam () that causes LIOB in the dermis layer () of the skin. The advantage is that damage to overlaying epidermis layers may be avoided by the use of the very local LIOB phenomenon.

Device and method for the treatment of skin, and use of the device

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Eindhoven, Netherlands

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