Bayer Aktiengesellschaft

Bayer Schering Pharma Ag

Siegfried Zaiss

Stefan Wohlfeil

Martin Beuck

Johannes-Peter Stasch

Andreas Knorr

Peter Fey

Rudolf H Hanko

Stanislav Kazda

Walter Hubsch

Ulrich E Muller

Matthias Muller-Gliemann

Thomas Kramer

Jurgen Dressel

Dirk Denzer

Hilmar Bischoff

Bruno Rosen

Matthias M uller-Gliemann

Ulrich E M Uller

Siegfried Goldmann

Otto Behner

J Urgen Dressel

Hartmund Wollweber

Thomas Kr Amer

Walter H Ubsch

Christoph Gerdes

James J Elting

Stefan Lohmer

Ozkan Yalkinoglu

Anke Domdey-Bette

Hartmut Wollweber

Wahed Ahmed Moradi

Nils Griebenow

Axel Kretschmer

Johannes Köbberling

Claudia Hirth-Dietrich

Hartmut Beck

Rudi Grutzmann

Marcus Bauser

Frank Süβmeier

Leila Telan

Ulf Brüggemeier

Niels Svenstrup

Barbara Albrecht

Mark Meininghaus

Maarten De Jonge

Hans-Georg Dellweg

Elisabeth Woltering

Martina Wuttke

Stanisiav Kazda

Petros Gatsios

Rudi Gr Utzmann

The invention relates to substituted [(phenylethanoyl)amino]benzamides and methods for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of inflammatory disorders such as, for example, cutaneous, respiratory tract and cardiovascular disorders such as, for example, arteriosclerosis and coronary heart disease.

Substituted [(phenylethanoyl)amino]benzamides

The phenylcyclohexylcarboxamides, some of which are known, are suitable as active compounds in medicaments, in particular in medicaments for the treatment of restenosis.

Use of phenylcyclohexylcarboxamides

Trisubstituted biphenyls are prepared by reacting corresponding pyridones with biphenylmethyl halogen compounds. The trisubstituted biphenyls can be employed as active compounds in medicaments.

Trisubstituted biphenyls

Heterotricyclically substituted phenyl-cyclohexanecarboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicaments.

Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid

Substituted pyridines and 2-oxo-1,2-dihydropyridines are prepared by reaction of correspondingly substituted halogenobenzenes with tetrazolylboronic acids. The substituted pyridines and 2-oxo-1,2-dihydropyridines according to the invention can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.

Substituted pyridines and 2-oxo-1,2-dihydropyridines

Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicaments.

Substituted indole derivatives are prepared by reacting appropriate carboxylic acids, if appropriate in the presence of auxiliaries, with appropriate amines. The substituted indole derivatives are suitable as active compounds in medicaments, in particular in medicaments for the treatment of arteriosclerosis and restenosis.

Substituted indole derivatives

Substituted biphenylpyridones can be prepared by alkylating pyridones on the nitrogen. The substituted biphenylpyridones are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments.

Substituted biphenylpyridones

Antihypertensive and antiatherosclerotic trisubstituted biphenyls of the formula ##STR1## in which R.sub.1 represents a carboxyl radical or represents a C.sub.1 -C.sub.8 -alkoxycarbonyl radical,

The substituted monopyridyl and bipyridyl derivatives are prepared by reacting substituted pyridine halides with phenylboronic acids. They are suitable for use as active compounds in medicaments for treating arterial hypertension and atherosclerosis.

Substituted monopyridylmethyl derivatives

Phenylglycinamides of heterocyclically substituted phenylacetic acid derivatives are prepared by reacting phenylacetic acids with glycinamides. The compounds can be used as active compounds in medicaments.

Phenylglycinamides of heterocyclically substitued phenylacetic acid

The invention relates to the new dimethyl 4-(4-chloro-3-trifluoromethylphenyl) -1-cyclopropyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, a process for its preparation and its use as a medicament in ischaemic diseases which are associated with disorders of the microcirculation. This action can occur both in the peripheral and in the cerebral vascular system.

Specific 1,4-dihydropyridine-3,5-dicarboxylic acid ester, and its

Novel substituted 2,4-imidazolidinediones are prepared either by reaction of .alpha.-aminocarboxylic acid derivatives with appropriately substituted biphenylmethyl halides and subsequent cyclization with isocyanates or by reaction of N-benzyl-substituted .alpha.-aminocarboxylic acid derivatives with tetrazolylphenylboronic acids or by reaction of sulphonyl-substituted benzyl halides with .alpha.-aminocarboxylic acid derivatives and subsequent cyclization with isocyanates. The compounds according to the invention can be employed as active compounds in medicaments, preferably for the treatment of arterial hypertension and arteriosclerosis.

Substituted 2,4-imidazolidinediones

Substituted imidazo[4,5-b]pyridines and benzimidazoles are prepared by reacting imidazo[4,5-b]pyridines or benzimidazoles with appropriately substituted benzyl halides. The substituted imidazo[4,5-b]pyridines or benzimidazoles can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.

Substituted imidazo[4,5-b]pyridines and benzimidazoles

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Wuppertal, Germany

Siegfried Zaiss