Biometra Biomedizinische Analytik Gmbh

Clondiag Chip Technologies Gmbh

Institut Fuer Physikalische Hochtechnologie E.v.

Institut Fur Physikalische Hochtechnologie E.v

Clondiag Gmbh

Siegfried Poser

Torsten Schulz

Eugen Ermantraut

Thomas Ullrich

Thomas Ellinger

Johann Michael Köhler

Ralf Ehricht

Klaus-Peter Möbius

Daniel Weicherding

Dieter Schimkat

Ulrich Dillner

Ulrich Bodner

Volker Baier

Jens Tuchscherer

Andreas Mokansky

Matthias Kirst

Karin Adelhelm

Joachim Fischer

The aim of the invention is to provide a device for duplicating and characterizing nucleic acids almost simultaneously and with a high sample throughput rate. The device consists of a chamber body with a recess whose edge sealingly holds an optically transparent chip. Said chip holds nucleic acids in individual spots on a detection surface. The chamber body is placed on an optically transparent chamber support with a bearing surface, in such a way that a capillary gap, which can be filled with a liquid sample, is formed between the detection surface of the chip facing towards the chamber support and said chamber support. The chamber body is provided with an inlet and an outlet, which are spatially separate from each other, and has a space, which laterally encompasses the chip and which has a gas reservoir. The chamber support is provided with heating elements.

Microchip matrix device for duplicating and characterizing nucleic acids

A miniaturized temperature-zone flow reactor, used for thermally controlled biochemical or molecular-biological processes, especially polymerase chain reaction (PCR) enables more efficient reactions by providing at least one closed flow path which is divided into three partial paths (A. . . An; B. . . Bn and BB. . . BBn&#x2212;1; C. . . Cn) with the reactor having three substrate chips (A; B; C) which are made of a material having a high heat conductivity, and which have defined channel sections that are spaced apart relative to each other, and are connected by a connecting chip (V) made of a poor heat-conductive material. The substrate chips (A; B; C) are maintained at different temperatures by various means, including the use of controlling heating elements in contact with the chips.

Miniaturized temperature-zone flow reactor

Miniaturized multi-chamber thermocycler

Miniaturized flow thermocycler

Growing community of inventors

Jena, Germany

Siegfried Poser