Bayer Aktiengesellschaft

Siegfried Petersen

Uwe Petersen

Erich Klauke

Hans Scheinpflug

Gerhard D Wolf

Hans-Joachim Kabbe

Gunther Nischk

Friedrich Hoffmeister

Karl Heinrich Mayer

Robert Bierling

Brigitte Hamburger

Wolfgang Wuttke

Hans-Egon Kunzel

Dieter Steinhoff

3-Aminoindazoles bearing a carbo(lower alkoxy), lower alkylamide or di(lower alkyl)amide group in the 1-or 2-position and further being optionally substituted in one or more of the 4-, 5-, 6- and/or 7-positions are analgesic, anti-inflammatory and antipyretic agents. The compounds, of which 3-amino-6-chloroindazole-1-carboxylic acid ethyl ester is a typical embodiment, are prepared through treatment of the appropriate 3-aminoindazole with a derivative of carbonic acid or through thermal isomerization.

3-Aminoindazole-1 and 2-carboxylic acid derivatives

7-Acylamino-desacetoxy-cephalosporanic acid esters are produced by heating a sulfoxide of 6-acylaminopenicillanic acid ester at a temperature of from about 60.degree.C to about 150.degree.C in the presence of a phenol catalyst. The 7-acylamino-desacetoxy-cephalosporanic acid esters produced are known per se and are useful as intermediates for the preparation of desacetoxy-cephalosporin derivatives which exhibit antibacterial activity.

7-Acylamino-desacetoxy-cephalosporanic acid esters and their production

2-Phenyl-4(3H)-quinazolones bearing a urethane or thiourethane group on the 2-phenyl substituent, a second urethane or thiourethane group on the benzo ring of the quinazolone nucleus and an alkyl, cycloalkyl or phenyl group in the 3-position are prepared by treating the corresponding bis-amino compound with an acid derivative or the corresponding bis(isocyanate) or bis(isothiocyanate) with an alcohol. The compounds, of which 2-[3'-(methoxycarbonylamino)-phenyl]-3-phenyl-6-methoxycarbonylamino-4-(3H )-quinazolone is a typical embodiment, are cytostatic agents.

Urethane derivatives of 2-phenyl-4(3H)-quinazolones

.beta.-PHENYL-.beta.-AZOLYL-NITROETHANES OF THE FORMULA ##SPC1## In which

.beta.-Phenyl-.beta.-azolyl-nitroethanes

Growing community of inventors

Leverkusen, Germany

Siegfried Petersen