The University of Texas System

Pg-txl Company, L.p.

Other

Micro Therapeutics, Inc.

William Cook, Europe A/s

Wallace Technologies

William Cook Europe S.a.

Sidney Wallace

David J Yang

Chun Li

Kenneth Carroll Wright

Dong-Fang Yu

Dusan Pavcnik

Andras Konya

Abdallah Cherif

Andr&aacute;s K&oacute;nya

Li-Ren Kuang

Andres Konya

Michael Wallace

Zuxing Kan

Wayne Tansey

E Delpassand

Chusilp Charnsangavej

A Cherif

András Kónya

S Quadri

Kennth C Wright

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis. Other embodiments include the coating of implantable stents for prevention of restenosis.

Water soluble paclitaxel prodrugs

The present invention concerns a design for dendritic poly(amino acid) polymer carriers, also known as nonlinear polymers, and their applications. These dendritic poly(amino acid) carriers have multiple functional groups at the polymer surface. In addition, they have heterofunctional groups on the poly(amino acid) side chains for drug or diagnostic agent attachment. They are designed to allow sufficient preservation of the binding affinity of the targeting ligand while conjugating therapeutic or diagnostic agents to the polymers. The present invention also describes methods of production of the polymer carriers and methods for the treatment or diagnosis of diseases employing the polymer carriers. The present invention also includes methods to introduce targeting moieties site-specifically to the end of polymer chains.

Dendritic poly (amino acid) carriers and methods of use

Water soluble paclitaxel derivatives

An occlusion method and apparatus. The occluder includes elastically deformable members and a jacket. The elastically deformable members are secured in spaced relation and extend in arcuate conformation therebetween. The jacket covers at least a portion of the elastically deformable members. The elastically deformable members are configured to become compressed upon application of a force and to recover the arcuate conformation upon removal of the fore to occlude a site.

Occlusion method and apparatus

A coil-type vasoocclusion device ( ) for establishing an embolus or vascular occlusion in a human or veterinary patient is adapted for introduction into the patient via a catheter ( ). The device ( ) first includes a coil ( ) having proximal and distal coil ends ( ) and a coil lumen ( ). The device ( ) also includes a core ( ) disposed in at least part of the coil lumen ( ), the core having proximal and distal core ends ( ). Only one core end ( or ) is directly affixed to a respective end ( or ) of the coil ( ); the other core end ( or ) is not directly connected to either end ( or ) of the coil ( ). The core ( ) is preferably nitinol in a superelastic state, being in other than its stress induced, martensitic condition. The device ( ) can include a thrombogenic material ( ) connected to or carried by the coil ( ). The coil ( ) is preferably adapted to achieve a suitable secondary shape ( ) when deployed from the catheter ( ). A medical device ( ) combining the catheter ( ), a pusher ( ), a coupling ( ) and the vasoocclusion device ( ) is also disclosed. The vasoocclusion device ( ) is easily repositioned in the vascular system, thereby ensuring proper deployment, and also enjoys a dislodging force about twice as great as comparable coil-type devices lacking the core ( ), substantially or completely preventing migration of the device ( ) after its deployment.

Vasoocclusion coil device having a core therein

A wire frame stent and stent delivery system for inserting the stent into the body.

Hoop stent

An occlusion method and apparatus. The occluder includes a elastically deformable members and a jacket. The elastically deformable members are secured in spaced relation and extend in arcuate conformation therebetween. The jacket covers at least a portion of the elastically deformable members. The elastically deformable members are configured to become compressed upon application of a force and to recover the arcuate conformation upon removal of the force to occlude a site.

Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble chelator, polyethylene glycol or polymer such as poly (1-glutamic acid) or poly (1-aspartic acid). Also disclosed are methods of using the compositions for treatment of tumors, auto-immune disorders such as rheumatoid arthritis and for prediction of paclitaxel uptake by tumors and radiolabeled DTPA-paclitaxel tumor imaging. Other embodiments include the coating of implantable stents for prevention of restenosis.

A multi-stage graft for implantation into a blood vessel is disclosed. The multi-stage stent graft may be used to repair aortic aneurysms. Each stage or layer may comprise radially compressible spring portions. The inner stages may be provided with or without a fabric covering. Also disclosed is a coaxial delivery system for the delivery and endovascular assembly of the multi-stage stent graft.

Delivery system and method for depolyment and endovascular assembly of

Growing community of inventors

Houston, TX, United States of America

Sidney Wallace