Hoffmann-la Roche Inc.

Sidney Teitel

Harvey Gurien

Clark William Perry

Manfred Weigele

John E Heveran

Antonino Focella

Richard W Kierstead

Hans Bruderer

Jay P O'Brien

James Gordon Christenson

John G Mullin

Keiji Nakamura

Arnold Brossi

Mitsuru Tateishi

Wilhelm Kloetzer

Substituted isoquinolines of the formula ##STR1## wherein R is a lower alkoxy, n is the integer zero or 1, and

Substituted isoquinolines

Aminoaryl esters and amino-lower alkyl amides of carboxy substituted barbiturates are linked via an amide linkage to carboxylated latex polymers to form reagents which are useful in a sensitive diagnostic test to detect the presence of barbiturates in body fluids.

Diagnostic test for barbiturates

A process for the preparation of .alpha.-methyl-carbazole-2-acetic acids, which comprises reacting an .alpha.-methyl-3-oxocyclohexane malonic acid di-lower alkyl ester with a substituted phenylhydrazine, and thereafter sequentially oxidizing and hydrolyzing the reaction product to obtain the desired acid, is described.

Carbazole melonates

Tetrahydro 2-carbazolyl methyl malonate derivatives

Carbazole methyl malonates

Aminophenyl esters of 5-carboxyalkyl barbituric acids

A novel derivative of ecgonine is described. This compound, 4-hyroxy-benzoyl ecgonine, is useful as a substrate for iodination with a radioactive isotope of iodine such as .sup.125 I. The resulting radiolabeled compound is useful in a radioimmunoassay for benzoyl ecgonine.

Ecgonine derivative

Racemic organic carboxylic acids are efficiently resolved into their enantiomers with antipodes of .alpha.-methyl-p-nitrobenzylamine.

Salts of N-formyl-6-chlorotryptophan and

Optical resolution of organic carboxylic acids

Salts of the .gamma.-lactone of (-)-threo-hydroxycitric acid with

The present invention relates to the preparation of novel rheadan-type alkaloids and to novel intermediates useful in the preparation thereof. The process utilizes as starting materials a known class of alkaloids of the narcotine or of the hydrastine type. Certain of the said novel intermediates are also pharmaceutically useful in and of themselves. Additionally, certain of the novel intermediates can be converted into other type alkaloids which are also pharmaceutically useful.

6-(3,4-Methylenedioxy-6-benzylalkylaminoethylphenylacetyl)benzoic acid

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Clifton, NJ, United States of America

Sidney Teitel