Baxter International Inc.

Baxter Healthcare Sa

Clintec Nutrition Company

Safety Diagnostice, Inc.

Sidney T Smith

Larry A Rosenbaum

John T Foley

David E Cerny

Steven H Giovanetto

Richard I Brown

Arnold C Bilstad

Gregg Nebgen

Atif M Yardimci

David V Bacehowski

Scott R Ariagno

Mark E Williamson

Bradley H Buchanan

Alan W Marttila

Paul Mario DiPerna

Marc C Bellotti

Michael R Prisco

David W Pennington

Mark Perry

William S Hurst

William Kolanko

Michele M Ulm

Lecon Woo

James G Bender

Stephen L Smith

Sindhu Ramachandran

Suchuan C Fan

Y Samuel Ding

Sue Rosenbaum, Legal Representative

Pierre Caloz

Jesse F Rodriguez

Michael T K Ling

Michael T Ling

Julian P Breillatt, Jr

Robert E Lewis

Michael R Keilman

Dean M Glash

Thomas R Lillegard

Adel M Sadik

David P Fisher

Joel R Mitchen

Robert L Gliniecki

Varsha Kalyankar

Keith Anderson

William S Hoerle

Edward G Oilschlager

Joan Zietlow

Richard J Brown

Carl W Jones

James Chase

Jeffrey R Sonderman

William L Schumacher

Melissa J Skelnik

William D Timmins

The present invention provides a receptacle () for a therapeutic fluid susceptible to deterioration on exposure to a gas such as oxygen or carbon dioxide. The receptacle () has walls of sheet material each including at least one layer forming a barrier essentially impermeable to such gas, and a seal sealing the walls together in a region thereof. A transfer tube () is sealed in the seal having a proximal end in the receptacle (), a distal end accessible from outside the receptacle (), a flow passage () extending between said proximal and distal ends, and a closure () blocking flow through the flow passage () adapted to be pierced by a tubular needle for transfer of therapeutic through the needle. The transfer tube () and closure () are essentially impermeable to said gas.

Multiple layer polymeric structure

A container () having a plurality of panels () joined together to form a sleeve (). The panels () each have an end edge that cooperate to define an imaginary plane (P) at one end of the sleeve (). The container () further has an end panel () connected to the panels () at the one end of the sleeve (). The end panel () has at least one portion extending beyond the imaginary plane (P). The supporting box () is provided to support the container (). A hanger system () is provided and is attached to the box (). The hanger system () supports an upper portion of the container () within the box (). The container () is also provided with a port closure () that provides both a sterile and gas permeable barrier.

Container support

The present invention provides a receptacle for a therapeutic fluid susceptible to deterioration on exposure to a gas such as oxygen or carbon dioxide. The receptacle has walls of sheet material each including at least one layer forming a barrier essentially impermeable to such gas, and a seal sealing the walls together in a region thereof. A transfer tube is sealed in the seal having a proximal end in the receptacle, a distal end accessible from outside the receptacle, a flow passage extending between said proximal and distal ends, and a closure blocking flow through the flow passage adapted to be pierced by a tubular needle for transfer of therapeutic through the needle. The transfer tube and closure are essentially impermeable to said gas.

High gas barrier receptacle and closure assembly

A method of processing blood establishes communication between a donor and a blood flow path and pumps whole blood from the donor into a container through the blood flow path. The method centrifugally separates the whole blood in the container into concentrated red blood cells and a plasma constituent. After the method interrupts communication between the donor and the blood flow path, the method pumps the concentrated red blood cells from the container to mix the concentrated red blood cells with a nutritive solution to restore the hematocrit of the concentrated red blood cells to a desired value. The method also removes the plasma constituent.

Centrifugation pheresis method

A vacuum demand valve for delivering a flowable material is disclosed. The valve has a housing having a proximal end, a distal end, an intermediate segment therebetween defining a passageway wherein the flowable substance can flow from the proximal end to the distal end. The housing can be a tubing. A valve member is located along the intermediate segment. The valve member has a closed condition wherein the flow of the flowable material from the proximal end to the distal end is stopped and an open condition wherein the flow of the flowable material from the proximal end to the distal end is unstopped. The valve member is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway for placing the valve member in the open condition.

Vacuum demand valve

A container ( ) having a plurality of panels ( ) joined together to form a sleeve ( ). The panels ( ) each have an end edge that cooperate to define an imaginary plane (P) at one end of the sleeve ( ). The container ( ) further has an end panel ( ) connected to the panels ( ) at the one end of the sleeve ( ). The end panel ( ) has at least one portion extending beyond the imaginary plane (P). The supporting box ( ) is provided to support the container ( ). A hanger system ( ) is provided and is attached to the box ( ). The hanger system ( ) supports an upper portion of the container ( ) within the box ( ). The container ( ) is also provided with a port closure ( ) that provides both a sterile and gas permeable barrier.

Gas permeable sterile closure

A vacuum demand value ( ) is capable of delivering a flowable material. The valve ( ) has a housing ( ) having a proximal end ( ), a distal end ( ), an intermediate segment ( ) therebetween defining a passageway ( ) wherein the flowable substance can flow from the proximal end ( ) to the distal end ( ). The housing ( ) can be tubing. A valve member ( ) is located along the intermediate segment ( ). The valve member ( ) has a closed condition wherein the flowable material from the proximal end ( ) to the distal end ( ) is stopped and an open condition wherein the flow of the flowable material from the proximal end ( ) to the distal end ( ) is unstopped. The valve member ( ) is biased in the closed condition and is responsive to a partial vacuum provided by the user through the passageway ( ) for placing the valve member ( ) in the open condition.

A multilayered film ( ) suitable for medical uses is coextruded in a machine direction and comprises a first layer ( ) defining a pair of peripheral edges ( ) extending in a direction parallel to the machine direction. The film has a second layer ( ) adhered to the first layer ( ). The second layer ( ) is positioned within the peripheral edges ( ) defining a stripe ( ).

Coextruded multilayer film materials and containers made therefrom

The present invention provides a multiple layer structure ( ) for fabricating medical products. The layer structure ( ) has a core layer ( ) of an ethylene vinyl alcohol copolymer having an ethylene content of about 25-45 mole percent, a solution contact layer of a polyolefin positioned on a first side of the core layer, an outer layer ( ) positioned on a second side of the core layer opposite the solution contact layer ( ), the outer layer ( ) being selected from the group consisting of polyamides, polyesters and polyolefins; two tie layers ( )&mdash;one of each adhered to the first and second sides of the core layer ( ) and positioned between the solution contact layer ( ) and the core layer ( ) and between the outer layer ( ) and the core layer ( ), and wherein the structure ( ) is produced in a cast coextrusion process.

Multilayered polymer structure for medical products

A multi-layer, flexible, gas-permeable film (,) suitable for forming a cell culture container (,), the film (,) comprising a first layer (,) composed of a polystyrene having a thickness within the range of 0.0001 inches to about 0.0010 inches and, a second layer (,) adhered to the first layer (,) composed of a polyolefin having a thickness within the range of 0.004 inches to about 0.015 inches.

Multilayer gas-permeable container for the culture of adherent and non-adherent cells

Growing community of inventors

Lake Forest, IL, United States of America

Sidney T Smith