American Cyanamid Company

Sidney Robert Safir

Lantz S Crawley

William J Fanshawe

Corris M Hofmann

Joseph William Epstein

Jeffery B Press

By Earle Cooley, Executor

Gretchen Ellen Wiegand, Deceased

Gretchen Ellen Wiegand

Substituted 3-azabicyclo[3.1.0]hexanes, acid addition salts, method of use and method of preparation are described. The compounds have anxiolytic and analgesic activity.

1-Phenyl-3-azabicyclo[3.1.0]hexanes

This application discloses novel substituted 4-(alkoxy or alkanoyloxy)-3-thiophenecarboxylic acids, esters, and amides which possess analgesic and antipyretic activity in warm-blooded animals.

3,4-Disubstituted thiophenes

This disclosure describes substituted 9-(4-methyl-1-piperazinyl)-4H-thieno[3,4-b][1,4]benzodiazepines which possess analgesic and anti-depressant activity and are also useful as anti-psychotic or neuroleptic agents.

4H-Thieno[3,4-b][1,4]benzodiazepines

Azabicyclohexanes, method of use and preparation of the same

This disclosure describes 10-[4-(substituted)-1-piperazinyl]thieno[3,4-b][1,5]benzoxazepines and 10-[4-(substituted-1-piperazinyl]thieno[3,4-b][1,5]benzothiazepines useful as anti-psychotic or neuroleptic agents.

10-(Piperazinyl)thieno[3,4-b][1,5]benzoxazepines and

This disclosure describes novel substituted thieno[3,4-b][1,5]benzoxazepin-10 (9H)-ones and thieno[3,4-b][1,5]benzothiazepin-10(9H)-ones which are useful as intermediates for the preparation of 10-[4-(substituted)-1-piperazinyl]thieno[3,4-b][1,5]benzoxazepines and 10-[4-(substituted)-1-piperazinyl]thieno[3,4-b][1,5]benzothiazepines which possess anti-psychotic or neuroleptic activity.

Thieno[3,4-b][1,5]benzoxazepin-10-ones and

Azabicyclohexanes

Substituted phenyl azabicyclohexanones, their method of preparation, and their conversion into substituted phenyl azabicyclohexanes which are active anxiolytic and analgesic agents.

Phenyl azabicyclohexanones

Phenyl and substituted phenyl 3-azabicyclo[3.1.0]-hexanes and method of preparing the same are described. They are useful as intermediates in preparing other physiologically active compounds.

Acylazabicyclohexanes

10-Substituted amino-4,9-dihydro-4H-thieno[3,4-b][1,5]benzodiazepines having neuroleptic, anti-depressant and analgesic activity.

Substituted benzodiazepines and method of use

Various substituted 6-(piperazinyl)10H-pyrido[3,2-b]thieno[3,4-e][1,4]-diazepines which have demonstrated anti-psychotic activity are disclosed.

Substituted

9-Aminoalkyl-4,9-dihydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-ones having anti-depressant and analgesic activity and which are intermediates for other compounds having central nervous system activity.

Substituted benzodiazepin-10-ones in treating pain and depression

This application discloses novel substituted enaminoketones which possess analgesic and antipyretic activity in warm-blooded animals.

Substituted enaminoketones

This invention resides in the field of p-fluorobenzoylpropyl-N-heterocyclic substituted quaternary salts useful as intermediates in the preparation of 1-p-fluorophenyl-4-N-heterocyclic-1-butanols, 1-p-fluorophenyl-4-N-heterocyclic-1-butanol esters and p-fluoro-.gamma.-heterocyclic butyrophenones having neuroleptic and analgesic activity. The butanols, butanol esters and butyrophenones from the subject matter of our concurrently filed and co-pending application Ser. No. 575,846, filed May 8, 1975, incorporated herein by reference.

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River Edge, NJ, United States of America

Sidney Robert Safir