Auransa Inc.

Sct Ii LLC

Sct Incorporated

Sidney Paul Elmer

Pek Yee Lum

Joseph C Wu

Zhong Zhong

Christopher G Armstrong

Viwat Visuthikraisee

Eithon Michael G Cadag

Eunhye Park

Thomas Bernard Freeman

Lisa Maria Lucia Pham

Kevin J Kim

Guanyi Huang

Andrew Asher Protter

Hak Jin Chang

Gregory R Luedtke

Anna Halberg

Rajaa Sukhun

The present disclosure provides a group of aromatic (e.g., pyridinyl, pyrimidinyl, pyrazinyl, or phenyl) diamidine analogs and pharmaceutically acceptable salts that are useful for treating a proliferative disease. The proliferative disease may include solid cancer or blood cancer. Compositions, methods of synthesizing the same and methods for treating various cancer using the analogs are disclosed herein. The present disclosure also provides pharmaceutical formulations comprising at least one of the compounds with a pharmaceutically acceptable carrier, diluent or excipient therefor.

Analogues of pentamidine and uses therefor

This disclosure provides methods and pharmaceutical compositions for reducing or eliminating cardiotoxicity, particularly cardiotoxicity induced by a cancer treatment or other therapy. In some cases, the methods and compositions prevent or reduce cardiotoxicity caused by anthracycline treatment. The methods provided herein often comprise administering a protective agent such as myricetin, tricetin, robinetin, ficetin, vitexin, quercetin, dihydrorobinetin, kaempferol, 7,3',4&#x2032;,5&#x2032;-tetrahydroxyflavone, and myricitrin in conjunction with the administration of a cancer drug or other treatment. They may comprise administering a protective agent in combination with dexrazoxane. The compositions provided herein include co-formulations of a protective agent with a different protective agent or with a cancer treatment (e.g., anthracycline drug).

Pharmaceutical compositions and methods for countering chemotherapy induced cardiotoxicity

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Palo Alto, CA, United States of America

Sidney Paul Elmer