Acist Medical Systems, Inc.

Sidney Donald Nystrom

Robert Foster Wilson

David J Hajicek

Martin G Hieb

Kendall R Waters

Edward R Miller

Khader Mohiuddin

Jason Fredrick Hiltner

Jason Hiltner

Touhid Khan

David Hajicek

This disclosure provides systems and methods for measuring fluid flow in a vasculature system of a patient. Some systems may include an injection system configured to inject a bolus of fluid into a vessel of a patient. Some systems may include a measurement engine configured to monitor the bolus of fluid in the vessel using measurement data generated by an intravascular measuring device. The measurement engine may determine a travel distance of the bolus of fluid and an elapsed time during which the bolus of fluid traversed the travel distance based on the measurement data. A fluid flow rate (e.g., velocity, volumetric flow) of the vessel may be calculated using the travel distance and the elapsed time.

Fluid flow measurement systems and methods

Intravascular systems can include a catheter having a proximal end, a distal end, a sensor located at the distal end configured to provide sensor information representative of one or more intravascular properties of a patient, and a plurality of magnetic domains. A magnetic pickup can be configured to output a pickup signal based on the magnetic field at the magnetic pickup produced by the plurality of magnetic domains. An intravascular processing engine can be in communication with the catheter sensor and the magnetic pickup. The intravascular processing engine can receive sensor information from the sensor and a position signal representative of the pickup signal. The intravascular processing engine can be used to determine position information related to the position of the catheter sensor and combine the received sensor information and corresponding determined position information.

Position sensing in intravascular processes

An intravascular imaging system can include a catheter, a position sensor, and an intravascular imaging engine for receiving information from the catheter and the position sensor. The position sensor can include a reference element and a movable element, which can have a movable element position that is correlated to the position of an imaging transducer in the catheter. The relative position between the movable element and a reference element can be determined and can correspond to the relative movement of the transducer within a patient's vasculature. The imaging engine can receive position information from the position sensor and image information from the catheter and generate a display using the received information. Because relative movement of the transducer can be determined, spatial relationships between sets of imaging data can be determined, and image data from multiple transducer locations can be combined into one image.

Position sensing in intravascular imaging

A syringe for injecting contrast injection media into a patient. An inlet valve system associated with the syringe, the inlet valve system operable with a contrast injection media having any viscosity within the range of about 1 cP to about 30 cP. An inlet valve system associated with the syringe, the inlet valve system including a valve member having a density of less than or equal to 1 gram per cubic centimeter. A contrast injector system with such a syringe.

Contrast media injector syringe inlet valve system

An injection system includes a syringe, which preferably includes larger and smaller inner diameters, and a plunger. A wiper sidewall of the plunger defines a cavity, into which a plunger shaft of the system is inserted, for moving the plunger, within the syringe, for fluid injection. The plunger includes a feature for engaging the shaft, and the sidewall preferably includes an expandable-contractible portion, in which the feature is formed. When the plunger is initially mounted within the larger inner diameter of the syringe, the portion of the sidewall is expanded and the feature of the plunger does not operably engage the inserted shaft. When the shaft moves the plunger into the smaller inner diameter of the syringe, the portion of the sidewall contracts and the feature operably engages the shaft. A deformable end wall of the plunger may be spaced apart from a distal terminal end of the inserted shaft.

Apparatus and methods for fluid pressurizing units of injection systems

According to preferred embodiments and methods of the present disclosure, a medical injection system employs a single pump for the injection of multiple fluids, rather than employing a pump for each type of fluid, for example, like the prior art system described above. Embodiments of pumps disclosed herein preferably include a disposable pump cartridge configured to be contained within a hull of a medical injection system, wherein the hull may be formed when a pressure plate member is closed against a base plate; and, when the pressure plate member is opened with respect to the base plate, the disposable pump cartridge may be removed and replaced.

Medical injection systems and pumps

A relatively compact protective apparatus for a pressure sensor includes a diaphragm, a plate, and a sleeve that couples the sensor to the apparatus; the diaphragm, whose perimeter edge is attached to the sleeve between the plate and sleeve, forms a compressible cavity in fluid communication, via an opening in the plate, with another cavity formed between the plate and the coupled sensor. A diameter of the diaphragm is relatively small, so the diaphragm includes an undulating zone for enhanced sensitivity in response to pressure. A configuration of the cavities and the opening allows a contained volume of air to transmit a relatively low pressure, via the diaphragm, to the coupled pressure sensor, yet prevents transmission of relatively high pressures to the pressure sensor. A wall of a system fluid circuit line or a manifold connector may be configured to incorporate the protective apparatus therein.

Monitoring low pressures in high pressure environments

A medical fluid injection system may include a powered injector and a fluid reservoir that contains a simulated contrast medium. The simulated contrast medium may exhibit a fluid flow property substantially equal to that of an active contrast medium but be devoid of any active contrast agent that provides contrast during diagnostic imaging. During operation, a syringe in the powered injector may be filled with the simulated contrast medium and then evacuated to discharge the simulated contrast medium from the syringe. The simulated contrast medium may be used to test and evaluate the performance of the powered injector prior to use in a medical procedure without exposing personnel to an active contrast agent or creating medical waste that contains the active contrast agent.

Simulated contrast injection medium

An injection system includes a syringe, which preferably includes larger and smaller inner diameters, and a plunger. A wiper sidewall of the plunger defines a cavity, into which a plunger shaft of the system is inserted, for moving the plunger, within the syringe, for fluid injection. The plunger includes a feature for engaging the shaft, and the sidewall preferably includes a expandable-contractible portion, in which the feature is formed. When the plunger is initially mounted within the larger inner diameter of the syringe, the portion of the sidewall is expanded and the feature of the plunger does not operably engage the inserted shaft. When the shaft moves the plunger into the smaller inner diameter of the syringe, the portion of the sidewall contracts and the feature operably engages the shaft. An optional deformable end wall of the plunger may be spaced apart from a distal terminal end of the inserted shaft.

A method of removing air from a flow path of a medical fluid injection system is described. An exemplary method performed by the medical fluid injection device includes delivering a first amount of fluid to a fluid flow path, isolating fluid flow along the flow path, forming a vacuum condition upstream of the fluid isolation, re-establishing fluid communications along the flow path, and delivering a second amount of fluid to the flow path.

Method and system for removing air from a flow path of a fluid injection device

One embodiment of the invention provides a method to purge air or liquid from a powered injection system. In this embodiment, the method includes driving a first pumping device in a first operational mode to inject an amount of a first liquid medium through disposable tubing and a disposable valve, driving the first pumping device in a second operational mode to deform the disposable valve, and driving a second pumping device to inject an amount of a second liquid medium through the disposable tubing and the deformed valve. In one embodiment, the first pumping device comprises a first syringe, the second pumping device comprises a second syringe, and the disposable valve comprises an elastomeric valve.

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Shoreview, MN, United States of America

Sidney Donald Nystrom