Northeastern University

Sidi A Bencherif

Thibault Colombani

Michail V Sitkovsky

Nasim Annabi

Ming Su

Adnan Memic

Stephen Hatfield

Liyuan Ma

Qingxuan Li

Devyesh Rana

Disclosed are nanocomposite oxygen-generating cryogels and their uses in reducing hypoxia in a biological tissue, such as a tumor. Methods of treating cancer with the disclosed cryogels are also provided.

Oxygen-generating cryogels

Disclosed herein are functionalized dopamine derivatives comprising an optionally substituted acrylic acid moiety and optionally a polyethylene glycol linking moiety. The functionalized dopamine derivatives are useful in cryogel formulations to improve the adhesivity of the cryogel, while preventing undesirable oxidation typically associated with dopamine-containing hydrogels and cryogels. Properties such as cryogel adhesivity, pore size, and interconnectivity are tunable features. Also provided herein are methods of treating a wound or promoting tissue regeneration with a cryogel of the invention or a formulation comprising such a cryogel.

Injectable, bioadhesive cryogel scaffolds for biomedical uses

Disclosed is a technology for assaying individual cells, in which the identity of each individual cell in an ordered array is determined from coordinates assigned to it, and can be readout at high throughput with microscope. The method is able to test responses of millions of identical cells in multiple chemical and physical processes with superior statistics power to facilitate deep data mining.

Coordinately-ordered single cells with individual identities for high-throughput assay

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Boston, MA, United States of America

Sidi A Bencherif