Columbia University

Cornell University

Siddhartha Mukherjee

Abdullah Mahmood Ali

Florence Borot

Lewis C Cantley

Timothy C Wang

Daniel Worthley

Marcus Goncalves

Benjamin Hopkins

Described herein are compositions and methods for treating a disease or disorder associated with PI3K signaling. For example, such compositions can include use of modulators of glucose metabolism, use of at least one kinase in the insulin-receptor/PI3K/AKT/mTOR pathway, and/or use of diet that influences the subject's metabolic state.

Combination therapy for PI3K-associated disease or disorder

Disclosed herein are compositions and methods relating to agents that target a lineage-specific cell-surface antigen and a population of hematopoietic cells that are deficient in the lineage-specific cell-surface antigen for immunotherapy of hematological malignancies.

CD33 exon 2 deficient donor stem cells for use with CD33 targeting agents

Disclosed herein are methods of administering an agent targeting a lineage-specific cell-surface antigen and a population of hematopoietic cells that are deficient in the lineage-specific cell-surface antigen for immunotherapy of hematological malignancies.

Compositions and methods for inhibition of lineage specific antigens

The invention is directed to osteochondroreticular stem cells and methods of using osteochondroreticular stem cells. In another aspect the invention is directed to a method of treating osteoarthritis or skeletal fractures using osteochondroreticular stem cells.

Growing community of inventors

New York, NY, United States of America

Siddhartha Mukherjee