Glaxosmithkline Biologicals Sa

Novartis Ag

Siddhartha Jain

Manmohan Singh

Derek T O'Hagan

David Skibinski

Stephanie Kay Dodd

Francesco Doro

Padma Malyala

David Skibinksi

Simona Cianetti

Sushma Kommareddy

Derek T O'HAGAN

Derek Thomas O'HAGAN

In one aspect, the present invention provides sterile microparticle compositions comprising biodegradable microparticles, which comprise at least one biodegradable polymer. In other aspects, the present invention provides methods of making and using such compositions as well as articles of manufacture and kits containing the same.

Irradiated biodegradable polymer microparticles

The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.

Homogenous suspension of immunopotentiating compounds and uses thereof

The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.

Compounds and compositions as TLR activity modulators

Particle compositions comprising adsorbed RNA replicons as well as methods of making and using the same are described.

Delivery of self-replicating RNA using biodegradable polymer particles

The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) polymeric particles and (c) a benzonaphthyridine compound, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides, inter alia, methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.

Benzonaphthyridine-containing vaccines

The invention is in the field of salt forms of an immunopotentiator compound and their formulation for in vivo use. In particular the invention relates to arginine salts.

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Troy, NY, United States of America

Siddhartha Jain