Cook Medical Technologies LLC

Edwards Lifesciences Cardiaq LLC

Edwards Lifesciences Corporation

Siddharth Vad

Blayne A Roeder

William John Havel

Michael P DeBruyne

Rick Hadley

J Brent Ratz

Alexander H Cooper

Luca Pesce

Jarin A Kratzberg

Edwin E Macatangay

Zachary Wagner

Tony C Hopkins

Travis Zenyo Oba

Lauren R Freschauf

Yaron Keidar

Glen Thomas Rabito

Sean Chambers

Garrett Dallas Johnson

Seung-Beom Yi

Gregory I Bak-Boychuk

David Robert Landon

Mark Robert Frye

Matthew A Peterson

Kevin M Golemo

Amanda French

Yuanlong Du

Arshad Quadri

James A Teague

Mark Allen Magnuson

Eugene Skelton

Kevin M Stewart

Julio Cesar Sanchez

Wen Hong Neoh

Anthony Wright

Yen Liao

Joel Ondersma

Johnny LeBlanc

Jeffry Scott Melsheimer

David Eric Orr

William Kurt Dierking

Matthew S Huser

Per Hendriksen

Ryan C Bradway

William F Moore

Davorin K Skender

Kevin Wilger

Stephan Haulon

Brandon J Davis

Nuno Dias

Erik Hughes

Nuno Diaz

Natalie Jones

Michael P Debruyne

Edwin Macatangay

Sean E Chambers

A prosthesis can be configured to grasp intralumenal tissue when deployed within a body cavity and prevent axial flow of fluid around an exterior of the prosthesis. The prosthesis can include an expandable frame configured to radially expand and contract for deployment within the body cavity and a valve body. The expandable frame can include a frame body and a supplemental frame. The valve body can include a plurality of leaflets and one or more intermediate components. The one or more intermediate components can couple at least a portion of the leaflets to the expandable frame. The prosthesis can include an annular flap positioned around an exterior of the expandable frame.

Replacement heart valve prosthesis

A mitral valve prosthesis includes an expandable frame having a proximal end, a distal end, and a middle portion. A plurality of tips extends from the proximal end of the frame for attachment to a delivery catheter. A plurality of anchors is disposed along the distal end of the frame and extend toward the proximal end for engaging tissue. An outer circumferential portion extends around the middle portion of the frame and is positioned radially outwardly of the frame. The outer circumferential portion preferably increases in diameter along a distal direction. A distal end of the outer circumferential portion is located distal of free ends of the anchors when the expandable frame is deployed. A valve body is positioned within an interior of the expandable frame and includes leaflets adapted to allow flow in a first direction and prevent flow in a second direction.

Replacement heart valves and methods of delivery

Devices, systems and methods are described herein a prosthesis for implantation within a lumen or body cavity and delivery systems for delivering the prosthesis to a location for implantation. A delivery system can include a plurality of components, including a flexible nose cone, multi-layer sheath, and pre-compressed shaft, which can be moveable relative to each other.

Replacement mitral valve, delivery system for replacement mitral valve and methods of use

A heart valve prosthesis for replacing a native mitral valve includes a self-expanding frame with a plurality of anchoring members disposed along the lower region. A valve body is positioned within the self-expanding frame and includes a plurality of leaflets configured to allow blood flow through the self-expanding frame in only one direction. A skirt surrounds the self-expanding frame and is spaced apart therefrom for contacting surrounding tissue and impeding blood flow around the self-expanding frame. The skirt may be reinforced with wires to help maintain a desired shape. The leaflets in the valve body are preferably connected to the self-expanding frame through one or more intermediate components such that the valve body is spaced radially inwardly from an inner surface of the self-expanding frame.

The present embodiments provide systems and methods for deploying at least a portion of a stent. In one embodiment, the system comprises a cannula having an outer surface, and at least one coiled member having proximal and distal ends and a plurality of turns disposed therebetween. One of the proximal and distal ends of the coiled member is secured to the outer surface of the cannula, and the other of the proximal and distal ends of the coiled member is unsecured relative to the outer surface of the cannula. A portion of a stent is looped around the unsecured end of the coiled member and disposed within spacing between adjacent turns of the coiled member. Rotation of the cannula subsequently causes the portion of the stent to disengage from the coiled member.

Systems and methods for deploying a portion of a stent using at least one coiled member

A delivery system for delivering an endovascular prosthesis is disclosed. A handle assembly is disposed at the distal end of the delivery system. The handle assembly includes a main handle and a second handle disposed at least partially on the main handle and rotationally moveable relative to the main handle. A trigger wire release mechanism is operatively coupled to the second handle. A sheath is operatively coupled to the second handle, such that rotation of the second handle relative to the main handle retracts the sheath in a distal direction. Rotation of the handle also moves the trigger wire release mechanism from a first position to a second position to retract one or more trigger wires.

Deployment handle for a pre-loaded iliac prosthesis delivery device

A mitral valve prosthesis includes an expandable frame having a proximal end, a distal end, and a middle portion. A plurality of tips extend from the proximal end of the frame for attachment to a delivery catheter. A plurality of anchors are disposed along the distal end of the frame and extend toward the proximal end for engaging tissue. An outer circumferential portion extends around the middle portion of the frame and is positioned radially outwardly of the frame. The outer circumferential portion preferably increases in diameter along a distal direction. A distal end of the outer circumferential portion is located distal of free ends of the anchors when the expandable frame is deployed. A valve body is positioned within an interior of the expandable frame and includes leaflets adapted to allow flow in a first direction and prevent flow in a second direction.

The present embodiments provide systems and methods for deploying at least a portion of a stent, comprising a retaining member having a main body. At least one slot is formed into the main body. The at least one slot comprises a circumferentially enclosed segment and an axial opening. A portion of a stent is restrained from moving radially outward when disposed within the circumferentially enclosed segment, and the portion of the stent is self-expandable radially outward when aligned with the axial opening.

Systems and methods for securing and releasing a portion of a stent

The present embodiments provide systems and methods for deploying at least a portion of a stent. In one embodiment, the system comprises a cannula having an outer surface, and an auger having a plurality of turns coupled to the outer surface of the cannula. A stent has a portion dimensioned to be disposed within a valley of the auger. Rotation of the cannula and the auger advances the portion of the stent in a predetermined longitudinal direction.

Systems and methods for deploying a portion of a stent using an auger-style device

The present embodiments provide stent-grafts. In one embodiment, a stent has proximal and distal ends, a plurality of strut segments disposed between the proximal and distal ends that enable expansion of the stent from a compressed state to a deployed state, and a series of distal apices disposed at the distal end of the stent. At least a portion of a first distal apex overlaps with graft material. First and second sutures are each coupled between a portion of the first distal apex and the graft material. The first and second sutures are positioned at different longitudinal zones that lack an axial overlap with one another.

Multi-level suture attachments for coupling a stent to graft material

An introducer for an endoluminal prosthesis and a methods for delivering a prosthesis within a body vessel are described. The introducer comprises pusher catheter having a lumen extending therethrough, the lumen being in communication with an opening formed in the sidewall of the pusher. A sheath is disposed over the pusher catheter and also has an opening formed in its sidewall. The sheath is longitudinally movable relative to the pusher catheter between a prosthesis delivery position and a prosthesis deployment position. When the sheath is in the deployment position, the opening formed in the sidewall of the pusher catheter is at least partially longitudinally aligned with the opening formed in the sidewall of the sheath. A wire may extend though the opening in the sheath, the opening in the pusher, through the lumen of the pusher and through a fenestration in a prosthesis to cannulate a branch vessel.

Introducer with side opening

The present invention relates to a prosthesis delivery device and to a handle assembly located at the distal end of the delivery device. The handle assembly has a main handle and a nut disposed on the main handle. The nut has a first configuration in which the nut is engaged with the outer surface of the main handle and a second configuration in which the nut is disengaged from the outer surface of the main handle. Disengaging the nut from the main handle facilitates quick sheath retraction and deployment of at least the distal end of the prosthesis as well as recapturing the proximal end of the device within the sheath.

Deployment handle for delivery device with mechanism for quick release of a prosthesis and re-sheathing of device tip

A delivery device and methods for deploying an endovascular prosthesis within the common and internal iliac arteries are described. The device comprises a pusher catheter having a proximal end and a pusher extension extending proximally therefrom. A tubular prosthesis having a side branch is releasably coupled to the pusher extension. An extension dilator extends proximally from the proximal end of the pusher catheter, extends at least partially along an external surface of the main tubular body, into a distal end of the side branch and exits a proximal end of the tubular prosthesis. The extension dilator can be tracked over a guide wire which serves to both position the device within a vessel and also to facilitate cannulation of an internal iliac artery.

Prosthesis delivery device with a pusher extension and an extension dilator

Growing community of inventors

Bloomington, IN, United States of America

Siddharth Vad