Myokardia, Inc.

Siddharth Madhwal

Rajdeep Anand

Kapil Kumar

Anurag Jain

Dinesh Jangid

Sunil Sharma

Priyanka Dhaka

Bharat Kumar

The present invention provides processes for preparation of substituted pyrazole compounds of formula II, that can be used as intermediates for preparation of substituted piperidine urea compounds useful for the treatment of dilated cardiomyopathy (DCM). Ris independently selected from F, C1-C4 alkyl, C1-C4 haloalkyl, Ris independently selected from H, F, C1-C4 alkyl, C1-C4 haloalkyl, Ris C1-C4 alkyl, Ris H or a protecting group and Ris selected from H, CI or trialkylsilyl.

Pyrazole compounds and preparation thereof

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Gurgaon, India

Siddharth Madhwal