Alexion Pharmaceuticals, Inc.

Siddharth Jindal

Paul P Tamburini

Douglas L Sheridan

Julian Chandler

Nimish Gera

Bridget Puffer

The disclosure provides engineered polypeptides that specifically bind to human complement component C5 and/or serum albumin. The disclosure also provides fusion proteins comprising such engineered polypeptides, wherein such fusion proteins may be multivalent and multi-specific fusion proteins. The disclosure further provides nucleic acid molecules that encode such engineered polypeptides or fusion proteins, and methods of making such engineered polypeptides or fusion proteins. The disclosure further provides pharmaceutical compositions that comprise such engineered polypeptides or fusion proteins, and methods of treatment using such engineered polypeptides or fusion proteins.

Growing community of inventors

Hamden, CT, United States of America

Siddharth Jindal