Boehringer Mannheim Gmbh

Roche Diagnostics Gmbh

Boehringer Mannhiem Gmbh

Sibylle Berner

Herbert Von Der Eltz

Hans-Georg Batz

Klaus Muhlegger

Cortina Kaletta

Cornelia Kruse-Mueller

Heinz-Hartmut Seliger

Christoph Kessler

Rudolf Seibl

Cornelia Kruse-Muller

Rudiger Ruger

Method for immobilizing nucleic acids by hybridizing the nucleic acid with a capture probe. The capture probe is protected against enzymatic extension and/or enzymatic degradation of the formed hybrid.

Method for electrochemiluminescent labeling of nucleic acid, use in

The subject matter of the invention is a modified phosphoramidite process for the synthesis of nucleotide sequences. By use of a modified nucleoside phosphoramidite it is possible to produce nucleotide sequences which have a modified phosphate residue.

Modified phosphoramidite process for the production of modified nucleic

Method for the specific detection of nucleic acids in a sample by reaction of the sample with one or several labelled nucleotide triphosphates and one or several enzymes which catalyse the production of a labelled nucleic acid B which contains this nucleotide, non-thermally denaturation, reacting the sample with a nucleic acid probe C which is sufficiently complementary to nucleic acid B and which contains at least one immobilizable group, if desired, contacting the nucleic acid hybrid D formed with a solid phase which recognizes and binds the immobilizable group, removing the liquid from the solid phase and determining the label on the solid phase as a measure for the presence of the nucleic acid.

Method for the sensitive detection of nucleic acids

Method for immobilizing nucleic acids using modified capture probes

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Augsburg, Germany

Sibylle Berner