Council of Scientific and Industrial Research

Department of Biotechnology Department of the Government of India

Sib Sankar Roy

Samir Bhattacharya

Mohua Mukherjee

Bikash Chandra Pal

Aditya Konar

Arun Bandyopadhyay

Subrata Dasgupta

Malabika Datta

Bir Bhanu Giri

Debleena Dey

Santu Bandopadhyay

Swapan Kumar Mandal

Tanushree Biswas

The present invention relates to a method of preventing and/or treating diabetes type 2, also, it relates to a method of augmenting Glut4 phosphorylation and Glut4 translocation to a target cell membrane to enhance insulin signal in a signal transduction pathway; further, it relates to a simplified and inexpensive process of obtaining extract and thereafter selectively, its active n-butanol fraction and active molecule Lupinoside PA (LPA), useful in preventing and/or treating diabetes type 2; and lastly, a pharmaceutical composition thereof.

Herbal extract and compound lupinoside and its analogues as anti-diabetic type II drugs from plant Pueraria tuberosa

The present invention relates to an adipocyte Insulin adpInsl with Insulin A and B chains of SEQ ID Nos. 1 and 2, a effective method of treating type 2 diabetes in a subject using adipocyte insulin, said method comprising steps of administering the insulin to a diabetic intraperitoneally, an Insulin gene of SEQ ID No. 3, a process of isolating protein Insulin from the adipocytes of the Carp, said method comprising steps of reverse transcripting RNA of adipocytes to obtain cDNA, using oligonucleotide primers of SEQ ID Nos. 5 and 6 to identify AdpInsl gene from cDNA, and deducing amino acid sequence from cDNA to obtain protein Insulin, and an adipocyte of Catla Catla useful for producing the said Insulin.

Adipocyte Insulin adpinsl with Insulin A and B chains and an effective method of treating type 2 diabetes in a subject using adipocyte insulin

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Calcutta, India

Sib Sankar Roy