General Electric Company

Ge Healthcare Bio-sciences Ab

Utc Fire & Security Americas Corporation, Inc.

Cytiva Sweden Ab

Siavash Yazdanfar

Dmitry Vladimirovich Dylov

Victor Petrovich Ostroverkhov

Stephen Barnett Solomon

Xinghua Wang

Stephen Johnson Lomnes

Chulmin Joo

Bernard Patrick Bewlay

Robert John Filkins

Peter William Lorraine

Vernon Jensen

David Martin Mills

Waseem Ibrahim Faidi

Mohamed Ahmed Ali

Edward James Nieters

Kevin Bernard Kenny

Evgenia Mikhailovna Kim

Ying Fan

Cristina Abucay Tan Hehir

Sora Kim

Jeremy C Durack

Jeffrey Michael Ashe

Frederick Wilson Wheeler

Vasile Bogdan Neculaes

Nicole Jessica Tibbetts

Floribertus P M Heukensfeldt Jansen

Ali Can

David A Mills

Hanno Ehring

Brian Michael Davis

Alberto Santamaria-Pang

Mark Marshall Meyers

Allen Lawrence Garner

Kenneth Roger Conway

Ying Mao

Evelina Roxana Loghin

Aharon Yakimov

Abhijit Vishwas Patil

Vignesh Thirukazhukundram Subrahmaniam

Floribertus Heukensfeldt Jansen

Andrzej Michal May

Sridhar Dasaratha

David LaVan Henderson

Rajesh Veera Venkata Lakshmi Langoju

Kajoli Banerjee Krishnan

Elizabeth Lockenberg Dixon

Mikael Hornqvist

Milos Todorovic

Krenar Tasimi

Mikael Anders Hornqvist

Nicole Jessica Tibbetts, Jr

Walter Vincent Dixon, Legal Representative

Deborah Stutz Lee

Stephen Andrew Latham

Zhangyi Zhong

A cleaning system and method use an ultrasound probe, a coupling mechanism, and a controller to clean equipment of a vehicle system. The ultrasound probe enters into an engine. The ultrasound probe emits ultrasound pulses and the coupling mechanism provides an ultrasound coupling medium between the ultrasound probe and one or more components of the engine. The controller drives the ultrasound probe to deliver the ultrasound pulse through the coupling medium to a surface of the one or more components of the engine. The ultrasound probe delivers the ultrasound pulse to remove deposits from the one or more components of the engine.

Ultrasonic cleaning system and method

A biopsy collecting device includes a needle unit comprising a biopsy specimen. Also, the biopsy collecting device includes an activator unit operatively coupled to the needle unit and including a channel at a bottom surface of the activator unit, wherein the channel is configured to detachably couple the biopsy collecting device to an attaching unit of a spectroscopy system.

System and method for attaching a biopsy collecting device to a spectroscopy system

Disclosed is an optical fiber arrangement for inducing coupling among propagation modes of light, said arrangement comprising a multimode optical fiber () having an input end () for receiving light and an output end () for emitting light, with a coupling inducing section () extending from said input end to said output end, and a holder () on which the optical fiber is arranged, wherein said multimode optical fiber has a non-circular cross section. Disclosed also is a system for measuring the absorption or determining the concentration of a substance, said system comprising at least one optical fiber arrangement.

Optical fiber arrangement for a system for measuring the light absorption or determining the concentration of a substance

A method in one embodiment includes acquiring optical image information with a detection unit configured to be operably coupled to a patient. The optical image information corresponds to microcirculation of the patient. The method also includes generating a microcirculation map of microvasculature of the patient using the optical image information. Further, the method includes generating a quantitative microcirculation index based on the microcirculation map, the quantitative microcirculation index corresponding to a condition of the patient.

Systems and methods for quantitative microcirculation state monitoring

A method for classifying a tissue sample of a biopsy specimen includes receiving a signal from at least one location of the tissue sample including a plurality of chromophores. Further, the method includes verifying whether the received signal comprises a predetermined amount of at least one of an attenuated illumination light and a re-emitted light. Also, the method includes determining that a spectrum of the received signal is within a predetermined range. In addition, the method includes processing the spectrum of the received signal to decompose the signal into a plurality of components. Furthermore, the method includes classifying tissue in the at least one location of the tissue sample into one of a plurality of tissue types based on the plurality of components.

Embodiments of devices, methods, and non-transitory computer readable media for monitoring a subject are presented. The monitoring device includes at least one sensor configured to monitor one or more physiological parameters of a subject and a processing unit operatively coupled to the sensor. The sensor comprises a plurality of radiation sources and detectors disposed on a flexible substrate in a designated physical arrangement. The processing unit is configured to dynamically configure an operational geometry of the sensor by controlling the intensity of one or more of the radiation sources and the gain of one or more of the detectors so as to satisfy at least one quality metric associated with one or more physiological parameters of the subject.

System and methods for physiological monitoring

A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal. Further, the OCT imaging system includes a controller having logic configured to perform an auto-ranging process to match the reference arm with the sample arm.

System and method for auto-ranging in optical coherence tomography

A spectroscopy system for auto-aligning a biopsy collecting device is presented. The spectroscopy system includes an illumination subsystem configured to emit an illumination light towards the biopsy collecting device, whereas the biopsy collecting device includes an activator unit and a needle unit and wherein the needle unit includes a cannula and a stylet having a biopsy specimen. Also, the spectroscopy system includes a fixation subsystem capable of holding the biopsy collecting device and configured to place the needle unit comprising the biopsy specimen across the illumination light. Further, the spectroscopy system includes a detection subsystem configured to receive a light comprising at least one of an attenuated illumination light and a re-emitted light from the needle unit. In addition, the detection subsystem is configured to send a control signal to align the needle unit at a predetermined position in the spectroscopy system based on the received light.

System and method for aligning a biopsy collecting device

A method for enhancing contrast in fluorescence imaging is provided. The method comprises providing a patterned illumination source for illuminating one or more regions corresponding to a scan step, scanning at least a portion of a surface of a subject using a plurality of scan steps, acquiring image frames corresponding to two or more scan steps, deducting a background fluorescence from the image frames corresponding to the two or more scan steps to form one or more processed image frames, and reconstructing an image using one or more of the processed image frames.

Methods and systems of optical imaging for target detection in a scattering medium

Systems and methods for imaging are presented. The method includes producing excitation light configured to induce fluorescence in an imaging agent that selectively binds to a target species in a region of interest (ROI) of a subject that also includes a background species. A first and a second spectral region are selected such that a determined difference between fluorescence corresponding to the target and the background species in the first spectral region differs from a corresponding difference in the second spectral region. First and second fluorescence images are generated from the fluorescence corresponding to the first and second spectral regions. Additionally, a fluorescence ratio for the background species in the first and second fluorescence image is determined. The first fluorescence image is then multiplied or divided with the determined ratio to generate an intermediate image that is subtracted from the second fluorescent image to reconstruct a background-subtracted image.

Systems and methods for nerve imaging

Systems and methods described herein employ multiple phase-contrast images with various relative phase shifts between light diffracted by a sample and light not diffracted by the sample to produce a quantitative phase image. The produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.

Quantitative phase microscopy for label-free high-contrast cell imaging

A method for classifying a tissue sample of a biopsy specimen into one of a plurality of classes is presented. The method includes receiving a light from at least one location of the tissue sample including a plurality of chromophores, wherein the received light comprises at least one of an attenuated illumination light and a re-emitted light. The method further includes processing a spectrum of the received light to determine a feature for each of the chromophores in the at least one location of the tissue sample. In addition, the method includes estimating a Z-score for each of the chromophores based on the determined feature. Also, the method includes classifying the tissue sample into one of the plurality of classes based on the estimated Z-score for each of the chromophores.

System and method for optical biopsy tissue characterization

In an imaging device having an objective and a stage for holding a sample to be imaged, a method for autofocusing is presented. The method includes determining a measured focus value corresponding to at least a first of a plurality of logical image segments. Further, the method includes imaging the first logical image segment using the measured focus value. The method also includes determining a predicted focus value for a second of the plurality of logical image segments using the measured focus value and a stored focus variation parameter. In addition, the method includes imaging the second logical image segment using the predicted focus value.

System and method for enhanced predictive autofocusing

A system, in one embodiment, includes an optical coherence tomography (OCT) imaging system having a light source configured to emit light. The OCT imaging system further includes a beam splitter configured to receive the light from the light source, split the light into a first light portion directed along a sample arm comprising a sample and a second light portion directed along a reference arm comprising a reference mirror, receive a first reflected light portion from the sample arm and a second reflected light portion from the reference arm, combine the first and second reflected light portions to obtain an interference signal at a detector. Further, the OCT imaging system includes a controller having logic configured to perform an auto-focusing process to determine the optimal position for a lens in the sample arm in order to bring the sample into focus.

System and method for auto-focusing in optical coherence tomography

Growing community of inventors

Niskayuna, NY, United States of America

Siavash Yazdanfar