Nano Targeting & Therapy Biopharma Inc.

National Taiwan University

Scinopharm Taiwan, Ltd.

Chan, Hardy Wai Hong

Si-Han Wu

Chung-Yuan Mou

Yi-Ping Chen

Cheng-Hsun Wu

Hardy Wai Hong Chan

Nai-Yuan Kou

Rong-Lin Zhang

Rong-lin Zhang

Tien-Chun Yang

Yi-ping Chen

The present disclosure relates to a method of preventing or treating brain cancers or brain metastases with mesoporous silica nanoparticles (MSNs) loaded with taxane-based chemotherapeutic drugs, in particular paclitaxel (PTX), cabazitaxel (CTX) or docetaxel (DTX), and the MSNs loaded with PTX, CTX or DTX.

Drug-loaded mesoporous silica nanoparticle for prevention and treatment of brain cancers or brain metastases

The present disclosure relates to a field of hollow silica nanospheres. Particularly, the present disclosure relates to silica nanoparticles as adjuvant to induce or enhance immune response or as carrier to deliver antigen to a body.

Silica nanosphere for immunotherapy

The disclosure provides a method for delivering an agent to posterior segment of an eye comprising administrating a pharmaceutical composition comprising the agent and mesoporous silica nanoparticles to the eye. An eye drop and a method for treating an ocular disease in a subject in need of such treatment are also provided.

Method for delivering an agent to posterior segment of an eye and uses thereof

Silica-based biomolecule carriers, compositions comprising the same and preparation methods and uses thereof for delivering biomolecules into a cell are provided. The silica-based biomolecule carrier comprises a porous core; a first bioactive moiety; a second bioactive moiety functionally associated with the first bioactive moiety; and linkers for respectively conjugating the first bioactive moiety and the second bioactive moiety to the porous core.

Silica-based biomolecule carrier, pharmaceutical composition comprising the same, preparation method and use thereof

The present disclosure relates to mesoporous silica nanoparticles (MSNs) with specific modifications as drug delivery systems containing both tumor targeting and blood-brain barrier (BBB) penetration properties suitable for cancer treatment and/or CNS disease treatment. The present disclosure also relates to method of preparing MSNs and the MSNs prepared by the method as described herein.

Surface-modified mesoporous silica nanoparticle for blood-brain barrier penetration,tumor targeting and cancer metastasis treatment, methods of production and uses thereof

The present invention relates to hollow silica nanoparticles as a drug delivery system loading bioactive ingredients. Particularly, the present invention relates to silica nanoparticles comprising multi-layered silica shells with one or more bioactive ingredients encapsulated within and their applications in drug delivery; and processes of preparing the same.

Growing community of inventors

Taichung, Taiwan

Si-Han Wu