Versi Group, LLC

Mount Cook Bio Sciences, Inc.

Shyi-Tai Jan

Kwen-Jen Chang

Kestutis P Biciunas

William Pendergast

Klim King

Xin Ma

Robert W McNutt, Jr

Robert Walton McNutt, Jr

Peter J Gengo

J Peter Gengo

Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.

Delta opioid receptor agonist compounds

Method of treating sexual dysfunctions with delta opioid receptor agonist compounds

Compositions and methods for treatment of a urinary tract dysfunction by administering to a subject in need of such treatment a pharmaceutical composition including a delta opioid receptor agonist in an amount effective to reduce the effects of the urinary tract dysfunction. The compositions may further include an additional active agent that is used to treat urinary tract dysfunctions, e.g., alpha-adrenergic agonists, anticholinergics, alpha-adrenergic antagonists and tricyclic antidepressants.

Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists

Diarylmethylpiperazine compounds are described, which are useful as mu and/or delta receptor opioid compounds, without central side effects. Pharmaceutical compositions containing such compounds are variously useful for peripheral or non-centrally mediated indications, including peripherally mediated and neuropathic pain, urogenital tract disorders, overactive bladder, urinary incontinence, sexual disorders, premature ejaculation, cough, lung edema, cardiac disorders, cardioprotection, gastro-intestinal disorders, diarrhea, irritable bowl syndrome, functional distention, immuno-modulation and anti-tumor activity.

Compositions of novel opioid compounds and method of use thereof

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Cary, NC, United States of America

Shyi-Tai Jan