Kaohsiung Medical University

Shyh-Chyun Yang

Chun-Nan Lin

Bai-Luh Wei

Huang-Yao Tu

A-Mei Huang

Chi-Feng Hung

Jih-Pyang Wang

Tzyh-Chyuan Hour

Dravidum Maitraie

Yeong-Shiau Pu

Ya-Ting Liou

Jan-Gowth Chang

Shen-Jeu Won

Kim-Hong Gan

Kai-Wei Lin

The present invention provides a chemical compound having the structure being one selected from a group consisting of wherein Ris one selected from a group consisting of COOCH, COOCHPh, CONHCH(CH)and CONHCH, Ris one selected from a group consisting of H, CHand CH(CH), Ris one selected from a group consisting of H, CH, CH(CH)and CHPh, and Ris one of CH(CH)and CH.

18&#x3b2;-Glycyrrhetinic acid derivatives and synthetic method thereof

Several ursolic acid derivatives and pharmaceutical compositions thereof are provided. The ursolic acid derivatives and the pharmaceutical compositions thereof have at least one of an anticancer and an anti-inflammatory effects. A method for increasing a reactive oxygen species in a cell is also provided. The method comprises a step of providing the cell with a pharmaceutical composition including an ursolic acid derivative.

Ursolic acid derivative and pharmaceutical composition thereof

The present invention is correlated with a derivative of 18&#x3b2;-glycyrrhetinic acid apt to suppressing cancer cells, which is selected from a group comprising of structure I and structure II: wherein residue Ris selected from one of CHand CHCH, residue Ris selected from one of COOCH, COOCHCH, COOCH(CH), CONHCHCH, CONHCHCHCH, and CONHCH(CH), and residue Ris selected from one of COOCHCH, COOCH(CH), CONHCHCH, CONHCHCHCH, and CONHCH(CH).

Derivative of 18&#x3b2;-glycyrrhetinic acid apt to suppress cancer cells

The present invention provides a chemical compound having the structure being one selected from a group consisting of  wherein Ris one selected from a group consisting of COOCH, COOCHPh, CONHCH(CH)and CONHCH, Ris one selected from a group consisting of H, CHand CH(CH), Ris one selected from a group consisting of H, CH, CH(CH)and CHPh, and Ris one of CH(CH)and CH.

18&#x3b2;-glycyrrhetinic acid derivatives and synthetic method thereof

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Kaohsiung, Taiwan

Shyh-Chyun Yang